Calcium-Binding Proteins and RAGE

From Structural Basics to Clinical Applications

  • Claus W. Heizmann

Part of the Methods in Molecular Biology book series (MIMB, volume 963)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Intracellular Ca2+-Measurements and Cation Interactions with EF-Hand Proteins

  3. Expression, Purification, Biochemical, and Structural Analyses and Cellular Localization

    1. Front Matter
      Pages 55-55
    2. Emilie Audran, Rania Dagher, Sophie Gioria, Marie-Claude Kilhoffer, Jacques Haiech
      Pages 57-72
    3. Günter Fritz
      Pages 87-97
    4. Anisuzzaman, M. Khyrul Islam, M. Abdul Alim, Naotoshi Tsuji
      Pages 127-146
    5. Johannes Hradsky, Marina Mikhaylova, Anna Karpova, Michael R. Kreutz, Werner Zuschratter
      Pages 147-169
  4. Interaction of Ca2+-Binding Proteins with Targets and Receptors/RAGE

    1. Front Matter
      Pages 171-171
    2. Steven M. Damo, Michael D. Feldkamp, Benjamin Chagot, Walter J. Chazin
      Pages 173-186
  5. RAGE-Meditated Cell Signaling and Pathology

    1. Front Matter
      Pages 237-237
    2. Ari Rouhiainen, Juha Kuja-Panula, Sarka Tumova, Heikki Rauvala
      Pages 239-263
    3. Katharina Anna Sterenczak, Ingo Nolte, Hugo Murua Escobar
      Pages 265-276
  6. Ca2+-Binding Proteins in Human Diseases and As Drug Targets

  7. Cell Line Authentication

    1. Front Matter
      Pages 339-339
    2. Robert S. McLaren, Yvonne Reid, Douglas R. Storts
      Pages 341-353
  8. Biomarkers, Diagnostic, Clinical Chemistry, and Gene Therapy

    1. Front Matter
      Pages 355-355
    2. Massimo Castagnola, Tiziana Cabras, Federica Iavarone, Chiara Fanali, Irene Messana
      Pages 357-371
    3. Ramona Astrand, Johan Undén, Bertil Romner
      Pages 373-384
    4. Danielle Hof, Roland Klingenberg, Arnold von Eckardstein
      Pages 385-406
    5. Patrick Most, Philip Raake, Christophe Weber, Hugo A. Katus, Sven T. Pleger
      Pages 407-420
  9. Back Matter
    Pages 421-424

About this book


A major direction in medical research leading to clinical applications  targets the regulation of intracellular calcium and the various human diseases associated with an altered homeostasis of this global second messenger. These diseases include, for example: cardiomyopathy, inflammation, brain disorders, diabetes and cancer. In Calcium Binding Proteins and RAGE: from Structural Basics to Clinical Applications, expert researchers in the field detail many of the methods which are now commonly used to study calcium binding proteins. These methods and techniques, such as calcium-measurements, screening methods, clinical chemistry, and therapy, are generally applicable to many other areas of basic and medical research as well as to diagnostics. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.


Authoritative and practical, Calcium Binding Proteins and RAGE: from Structural Basics to Clinical Applications underlines the diagnostic and clinical importance of this family of proteins in human diseases and as drug targets.


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Editors and affiliations

  • Claus W. Heizmann
    • 1
  1. 1.Div of Clinical Chem & Biochem, Department of PediatricsUniversity of ZürichZürichSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-229-2
  • Online ISBN 978-1-62703-230-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site