Teratogenicity Testing

Methods and Protocols

  • Paul C. Barrow

Part of the Methods in Molecular Biology book series (MIMB, volume 947)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Keith P. Hazelden
    Pages 31-36
  3. Steve Barton
    Pages 57-72
  4. Paul C. Barrow, François Spézia
    Pages 73-80
  5. Paul C. Barrow, Linda Allais
    Pages 81-89
  6. François Spézia, Paul C. Barrow
    Pages 91-94
  7. Mariline Leroy, Linda Allais
    Pages 95-109
  8. Edward Marsden, Mariline Leroy
    Pages 111-123
  9. Lucie Reynaud, Edward Marsden
    Pages 125-137
  10. Linda Allais, Lucie Reynaud
    Pages 139-156
  11. Peter A. McAnulty
    Pages 157-167
  12. Antje Fuchs, Eberhard Buse, Gerhard F. Weinbauer
    Pages 169-183
  13. Gerhard F. Weinbauer, Joerg Luft, Antje Fuchs
    Pages 185-200
  14. Lucie Reynaud, Audrey Jocteur-Monrozier
    Pages 201-213
  15. Sergio X. Vasquez, Neha Shah, Alan M. Hoberman
    Pages 223-231
  16. Mariline Leroy, Audrey Jocteur-Monrozier
    Pages 243-253
  17. Eve Mylchreest, Stephen B. Harris
    Pages 275-294
  18. Paul C. Barrow, Lucie Reynaud
    Pages 295-309
  19. Bengt R. Danielsson
    Pages 311-325
  20. Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, Nisha Sipes
    Pages 343-374
  21. Sjors H. W. Schulpen, Aldert H. Piersma
    Pages 375-382
  22. Kimberly C. Brannen, Jeffrey H. Charlap, Elise M. Lewis
    Pages 383-401
  23. Cindy Zhang, Julie Panzica-Kelly, Karen Augustine-Rauch
    Pages 423-450
  24. Joshua F. Robinson, Aldert H. Piersma
    Pages 451-473
  25. James E. Ridings
    Pages 575-586
  26. Back Matter
    Pages 587-601

About this book


Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular Biology™ series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.


Alternative methods Biologics DART Data interpretation Fetal examination Pesticides REACH Reproductive toxicology Risk assessment Teratology

Editors and affiliations

  • Paul C. Barrow
    • 1
  1. 1.CiToxLABEvreuxFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-130-1
  • Online ISBN 978-1-62703-131-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site