LC-MS in Drug Analysis

Methods and Protocols

  • Loralie J. Langman
  • Christine L. H. Snozek

Part of the Methods in Molecular Biology book series (MIMB, volume 902)

Table of contents

  1. Front Matter
    Pages i-x
  2. Catherine Hammett-Stabler, Steven W. Cotten
    Pages 1-13
  3. Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, Denis C. Lehotay
    Pages 29-41
  4. Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, Denis C. Lehotay
    Pages 53-64
  5. David M. Garby, Lynn A. Cheryk
    Pages 65-73
  6. Christine L. H. Snozek, Matthew W. Bjergum, Loralie J. Langman
    Pages 91-103
  7. Robert A. Middleberg, Joseph Homan
    Pages 105-114
  8. François-Ludovic Sauvage, Pierre Marquet
    Pages 129-138
  9. Robert A. Middleberg, Joseph Homan
    Pages 139-148
  10. Eric W. Korman, Loralie J. Langman, Christine L. H. Snozek
    Pages 149-156
  11. Robert A. Middleberg, Joseph Homan
    Pages 157-166
  12. Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, Gwendolyn A. McMillin
    Pages 175-184
  13. Elizabeth R. Kiely, Heather M. Antonides
    Pages 185-199
  14. Simone M. Tchu, Kara L. Lynch, Alan H. B. Wu
    Pages 211-222
  15. Back Matter
    Pages 223-224

About this book


Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance.  The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques.  The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.


LC-MS/MS procedures analytes drug screening assays liquid chromatography mass spectrometry toxicology

Editors and affiliations

  • Loralie J. Langman
    • 1
  • Christine L. H. Snozek
    • 2
  1. 1.Mayo ClinicRochesterUSA
  2. 2.Mayo ClinicRochesterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-933-4
  • Online ISBN 978-1-61779-934-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site