Immunotoxicity, Immune Dysfunction, and Chronic Disease

  • Rodney R. Dietert
  • Robert W. Luebke

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Keith D. Salazar, Rosana Schafer
      Pages 3-30
    3. Rodney R. Dietert, Robert W. Luebke
      Pages 31-47
  3. Allergic Diseases

    1. Front Matter
      Pages 49-49
    2. David M. Lehmann, Marc A. Williams
      Pages 51-101
    3. David A. Basketter, John P. McFadden
      Pages 103-126
    4. Christal C. Bowman
      Pages 127-149
  4. Autoimmune and Inflammatory Diseases and Conditions

    1. Front Matter
      Pages 151-151
    2. Anne Cooke, Paola Zaccone
      Pages 153-170
    3. Jean C. Pfau
      Pages 171-192
    4. Moran Landau Rabbi, Ilan Ben-Zvi, Nancy Agmon-Levin, Yehuda Shoenfeld
      Pages 193-213
    5. Milo Careaga, Judy Van de Water, Paul Ashwood
      Pages 253-269
    6. DeLisa Fairweather
      Pages 271-289
    7. Celine A. Beamer, Benjamin P. Seaver, David M. Shepherd
      Pages 313-343
  5. Infections and Cancer

    1. Front Matter
      Pages 387-387
    2. Joseph Wiemels
      Pages 399-415
  6. Prevention of Chronic Diseases

    1. Front Matter
      Pages 417-417
    2. Rodney R. Dietert, Jamie C. DeWitt, Robert W. Luebke
      Pages 419-440
  7. Back Matter
    Pages 441-451

About this book


Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus.  Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction.  Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions.  This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.   


Chronic disease Immune dysfunction Immune system Immunology Immunotoxicity Robert Luebke Rodney R. Dietert Toxicology

Editors and affiliations

  • Rodney R. Dietert
    • 1
  • Robert W. Luebke
    • 2
  1. 1.College of Veterinary Medicine, Dept. Microbiology & ImmunologyCornell UniversityIthacaUSA
  2. 2.National Health and Environmental Effects, Research LaboratoriesUS Environmental Protection AgencyResearch Triangle ParkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-61779-811-5
  • Online ISBN 978-1-61779-812-2
  • Series Print ISSN 2168-4219
  • Series Online ISSN 2168-4235
  • Buy this book on publisher's site