Studies on Men's Health and Fertility

  • Ashok Agarwal
  • R. John Aitken
  • Juan G. Alvarez

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Basic Research

    1. Front Matter
      Pages 1-1
    2. Geoffry N. De Iuliis, Bruce V. King, R. John Aitken
      Pages 3-20
    3. Eve de Lamirande, Cristian O’Flaherty
      Pages 57-94
    4. Juan G. Alvarez, R. John Aitken
      Pages 119-130
    5. Bernard Robaire, Catriona Paul, Johanna Selvaratnam
      Pages 131-148
    6. Koji Shiraishi
      Pages 149-178
    7. Monika Fraczek, Anna Czernikiewicz, Maciej Kurpisz
      Pages 179-205
    8. Tamer M. Said, Fariba Khosravi
      Pages 237-254
  3. Clinical Practice

    1. Front Matter
      Pages 255-255
    2. David Benjamin, Rakesh K. Sharma, Arozia Moazzam, Ashok Agarwal
      Pages 257-273
    3. R. John Aitken, Geoffry N. De Iuliis, Mark A. Baker
      Pages 275-299
    4. Ralf Henkel
      Pages 301-323
    5. Dikmen Dokmeci
      Pages 355-398
    6. Armand Zini, Naif Al-hathal
      Pages 399-415
    7. Fábio Firmbach Pasqualotto, Eleonora Bedin Pasqualotto
      Pages 417-431
    8. Tamer M. Said, Constanze Fischer-Hammadeh, Mohammed Hamad, Khaled Refaat, Mohamad Eid Hammadeh
      Pages 433-448
    9. Mohamad Eid Hammadeh, Mohammed Hamad, Khaled Refaat, Tamer M. Said, Constanze Fischer-Hammadeh
      Pages 449-483
    10. Ashok Agarwal, Anthony H. Kashou, Lucky H. Sekhon
      Pages 485-516
    11. Margot Flint, Ashok Agarwal, Stefan S. du Plessis
      Pages 517-533
    12. Tamer M. Said, Sheila R. Gokul, Ashok Agarwal
      Pages 535-549
    13. Enzo Vicari, Sandro La Vignera, Aldo E. Calogero
      Pages 551-570
    14. Anthony H. Kashou, Stefan S. du Plessis, Ashok Agarwal
      Pages 571-590
    15. Biljana Musicki, Arthur L. Burnett
      Pages 617-643
  4. Back Matter
    Pages 645-671

About this book


Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date.  The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified.  From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. 

Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance.  It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic.  With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms.  In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.


Ashok Agarwal Fertility Juan G. Alvarez Male Health Oxidative Stress R. John Aitken

Editors and affiliations

  • Ashok Agarwal
    • 1
  • R. John Aitken
    • 2
  • Juan G. Alvarez
    • 3
  1. 1.Center for Reproductive Medicine, Department of UrologyCleveland ClinicClevelandUSA
  2. 2.Faculty of Science and IT, Department of Biological SciencesUniversity of NewcastleCallaghanAustralia
  3. 3., Department of Male InfertilityCentro AndrogenLa CoruñaSpain

Bibliographic information