Nanopore-Based Technology

  • Maria E. Gracheva

Part of the Methods in Molecular Biology book series (MIMB, volume 870)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Single Molecule Characterization with Biological Nanopores

    1. Front Matter
      Pages 1-1
    2. John J. Kasianowicz, Joseph E. Reiner, Joseph W. F. Robertson, Sarah E. Henrickson, Claudio Rodrigues, Oleg V. Krasilnikov
      Pages 3-20
    3. Mohammad M. Mohammad, Liviu Movileanu
      Pages 21-37
    4. Robert Purnell, Jacob Schmidt
      Pages 39-53
    5. Céline Merstorf, Benjamin Cressiot, Manuela Pastoriza-Gallego, Abdel Ghani Oukhaled, Laurent Bacri, Jacques Gierak et al.
      Pages 55-75
  3. Biomolecule Characterization with Artificial Membranes

    1. Front Matter
      Pages 77-77
    2. Ryan C. Rollings, David S. McNabb, Jiali Li
      Pages 79-97
    3. Alon Singer, Ben McNally, Ruby Dela Torre, Amit Meller
      Pages 99-114
    4. Lorenz J. Steinbock, Ulrich F. Keyser
      Pages 135-145
  4. Theory and Computer Simulations for Single Molecule Characterization with Protein and Solid-State Nanochannels

    1. Front Matter
      Pages 147-147
    2. Massimiliano Di Ventra, Matt Krems, James Wilson, Yuriy V. Pershin
      Pages 149-163
    3. David B. Wells, Swati Bhattacharya, Rogan Carr, Christopher Maffeo, Anthony Ho, Jeffrey Comer et al.
      Pages 165-186
    4. Dmitriy V. Melnikov, Alexey Nikolaev, Jean-Pierre Leburton, Maria E. Gracheva
      Pages 187-207
  5. Novel Materials and Devices for Biomolecular Characterization

    1. Front Matter
      Pages 209-209
    2. Chris A. Merchant, Marija Drndić
      Pages 211-226
    3. Adam R. Hall, Johannes M. Keegstra, Matthew C. Duch, Mark C. Hersam, Cees Dekker
      Pages 227-239
    4. Zhijun Jiang, Mirna Mihovilovic, Erin Teich, Derek Stein
      Pages 241-264
  6. Back Matter
    Pages 265-267

About this book


Nanopores are vital biological features, described as tiny holes in cellular membranes used for recognition and transport of ions and molecules between compartments within the cell, as well as between the extracellular environment and the cell itself. Their study, ever growing in esteem, leads toward the promise of ultra-fast sequencing of DNA molecules with the ultimate goal of building a nanoscale device that will make rapid and cheap DNA sequencing a reality.  In Nanopore-Based Technology, expert researchers in the forefront of the field explore the cutting-edge of nanopore technology for single molecule sensing, detection, and characterization.  Divided into four convenient parts, this volume covers single molecule characterization techniques utilizing biological pores, methods for biomolecule characterization with nanoporous artificial membranes, computational studies of the biomolecule confined within the nanopore environment, as well as techniques that use novel materials in conjunction with nanopore sensing.  Written for the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for achieving optimal results.


Authoritative and state-of-the-art, Nanopore-Based Technology serves as an excellent representation of the present-day available techniques for biomolecule characterization with nanoporous membranes in order to guide researchers toward developing the next generation of technologies for fast and cheap DNA sequencing with practically no limitations on the read lengths.


Artificial membranes Biological nanopores Computer simulations DNA sequencing Nanopore technology Nanoporous membranes Single molecule characterization

Editors and affiliations

  • Maria E. Gracheva
    • 1
  1. 1., Department of PhysicsClarkson UniversityPotsdamUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-772-9
  • Online ISBN 978-1-61779-773-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site