Cancer Epigenetics

Methods and Protocols

  • Ramona G. Dumitrescu
  • Mukesh Verma

Part of the Methods in Molecular Biology book series (MIMB, volume 863)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Early Epigenetic Events in Cancer

    1. Front Matter
      Pages 1-1
    2. Ramona G. Dumitrescu
      Pages 3-14
    3. Alok Mishra, Mukesh Verma
      Pages 15-31
  3. Cancer Specific Type Epigenetic Changes

    1. Front Matter
      Pages 33-33
    2. Wolfgang Goering, Michael Kloth, Wolfgang A. Schulz
      Pages 47-66
    3. Wun-Jae Kim, Yong-June Kim
      Pages 111-118
    4. Stefan Deneberg
      Pages 119-137
    5. Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, Michael D. Taylor
      Pages 139-153
    6. Qiang Lu, Dehua Ma, Shuping Zhao
      Pages 155-176
    7. Sharad Khare, Mukesh Verma
      Pages 177-185
    8. Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, Maria J. Worsham
      Pages 187-206
    9. Mario Pérez-Sayáns García, Abel García-García
      Pages 207-219
    10. Krishna K. Banaudha, Mukesh Verma
      Pages 241-251
    11. L. M. S. Seeber, P. J. van Diest
      Pages 253-269
  4. Methods and Technologies used for Epigenetic Changes’ Detection

    1. Front Matter
      Pages 271-271
    2. Katja Biewusch, Marie Heyne, Robert Grützmann, Christian Pilarsky
      Pages 273-280
    3. Hilary A. A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, Ken I. Mills
      Pages 281-292
    4. Richard N. Armstrong, Hilary A. A. Colyer, Ken I. Mills
      Pages 293-302
    5. Alexander Unterberger, Adrian M. Dubuc, Michael D. Taylor
      Pages 303-317
    6. Hilary A. A. Colyer, Richard N. Armstrong, Ken I. Mills
      Pages 319-328
    7. Hilary A. A. Colyer, Margaret Dellett, Ken I. Mills
      Pages 329-339
  5. Factors that Influence the Epigenetic Changes in Cancer

    1. Front Matter
      Pages 341-341
    2. Gabriela Riscuta, Ramona G. Dumitrescu
      Pages 343-358
    3. Unhee Lim, Min-Ae Song
      Pages 359-376
    4. L. Joseph Su
      Pages 377-393
    5. Sulma I. Mohammed, Sanya Springfield, Rina Das
      Pages 395-410
    6. Jovanny Zabaleta
      Pages 411-435
  6. Epigenetic Epidemiology

    1. Front Matter
      Pages 437-437
    2. Richard N. Armstrong, Hilary A. A. Colyer, Ken I. Mills
      Pages E1-E1
  7. Back Matter
    Pages 481-492

About this book


The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols, expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations  used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.


Epigenetics cancer cancerous cells environmental factors gene expression genetic factors methylation patterns normal cells tissue tumor

Editors and affiliations

  • Ramona G. Dumitrescu
    • 1
  • Mukesh Verma
    • 2
  1. 1.School of MedicineSaba UniversitySabaDutch Antilles
  2. 2.National Institutes of Health (NIH), Div. Cancer Control &National Cancer InstituteBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-611-1
  • Online ISBN 978-1-61779-612-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site