Studies on Retinal and Choroidal Disorders

  • Robert D. Stratton
  • William W. Hauswirth
  • Thomas W. Gardner
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Marco A. Zarbin, Philip J. Rosenfeld
    Pages 1-46
  3. Bärbel Rohrer, Mausumi Bandyopadhyay, Kannan Kunchithapautham, Joshua M. Thurman
    Pages 47-63
  4. Hao Wang, Biren Zhao, Ivan Vrcek, John M. Johnston, Yu-Guang He
    Pages 85-93
  5. L. S. Murdaugh, A. E. Dill, J. Dillon, J. D. Simon, E. R. Gaillard
    Pages 113-139
  6. Anisse Saadi, John D. Ash, Thierry N. Ngansop, Debra A. Thompson, Anne Kasus-Jacobi
    Pages 165-180
  7. Parameswaran G. Sreekumar, David R. Hinton, Ram Kannan
    Pages 181-201
  8. Stuart G. Jarrett, Alfred S. Lewin, Michael E. Boulton
    Pages 203-239
  9. Guorui Dou, Ram Kannan, David R. Hinton
    Pages 241-258
  10. Sonia Mehta, Joshua L. Dunaief
    Pages 259-275
  11. Qiuhong Li, Amrisha Verma, Astra Dinculescu, Alfred S. Lewin, William W. Hauswirth
    Pages 307-320
  12. Dan-Ning Hu, Joan E. Roberts, Richard Rosen, Steven A. McCormick
    Pages 337-354
  13. Milam A. Brantley Jr., Melissa P. Osborn, Jiyang Cai, Paul Sternberg Jr.
    Pages 367-397
  14. Xue Cai, Sudipta Seal, James F. McGinnis
    Pages 399-418

About this book

Introduction

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid.  Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of  oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina.  It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina.

 

A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of  cerium oxide nanoparticle reduction of oxidative stress.  Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of  prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell.  The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

Keywords

AMD Choroidal Disorder NAPDH Oxidative Stress Retinal Stratton VEGF

Editors and affiliations

  • Robert D. Stratton
    • 1
  • William W. Hauswirth
    • 2
  • Thomas W. Gardner
    • 3
  1. 1.Vero BeachUSA
  2. 2.Department of OphthalmologyUniversity of FloridaGainesvilleUSA
  3. 3.Molecular and Integrative Physiology, Ophthalmology and Visual SciencesKellogg Eye CenterAnn ArborUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-61779-606-7
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-61779-605-0
  • Online ISBN 978-1-61779-606-7
  • About this book