Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

  • Antonio Russo
  • Stefano Iacobelli
  • Juan Iovanna

Part of the Current Clinical Pathology book series (CCPATH)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, Giuseppe Tonini
    Pages 1-11
  3. Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, John W. M. Martens
    Pages 13-25
  4. Daniele Fanale, Lidia Corsini, Sergio Rizzo, Antonio Russo
    Pages 27-33
  5. Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybył, Maria Debiec-Rychter
    Pages 35-50
  6. Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, Nelson Dusetti
    Pages 51-79
  7. Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, Jia Wei
    Pages 81-94
  8. Laura Ottini, Mario Falchetti, Gabriella Nesi
    Pages 95-113
  9. Alessandro Lugli, Inti Zlobec
    Pages 115-136
  10. Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, Salvatore Spicuglia
    Pages 137-152
  11. Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, Giancarlo Troncone
    Pages 165-178
  12. Back Matter
    Pages 179-182

About this book


Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.


Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.


Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Editors and affiliations

  • Antonio Russo
    • 1
  • Stefano Iacobelli
    • 2
  • Juan Iovanna
    • 3
  1. 1.Department of Surgical and, Oncological SciencesUniversity of PalermoPalermoItaly
  2. 2., National Consortium for Research onUniversity D’AnnunzioChietiItaly
  3. 3.INSERM U624MarseilleFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-61779-357-8
  • Online ISBN 978-1-61779-358-5
  • Buy this book on publisher's site