Animal Models of Movement Disorders

Volume I

  • Emma L. Lane
  • Stephen B. Dunnett

Part of the Neuromethods book series (NM, volume 61)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Generic Methods of Assessment

    1. Front Matter
      Pages 1-1
    2. Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, Ralph Hillman
      Pages 55-63
    3. Sabine M. Hölter, Lisa Glasl
      Pages 109-133
    4. Mathias Hoehn
      Pages 135-149
    5. Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress, David L. Wokosin, D. James Surmeier
      Pages 191-220
    6. Shilpa P. Rao, Véronique M. André, Carlos Cepeda, Michael S. Levine
      Pages 221-239
  3. Dopamine Systems

    1. Front Matter
      Pages 241-241
    2. Ralf Kühn, Daniela Vogt-Weisenhorn, Wolfgang Wurst
      Pages 243-265
    3. Eduardo M. Torres, Stephen B. Dunnett
      Pages 267-279
    4. Gaynor A. Smith, Andreas Heuer
      Pages 281-297
    5. Stephen B. Dunnett, Eduardo M. Torres
      Pages 299-315
    6. Hanna S. Lindgren, Emma L. Lane
      Pages 337-351
    7. Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, Michael W. Jakowec
      Pages 353-369
  4. Back Matter
    Pages 437-447

About this book


Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems. 


Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.


Assessment methods Behavioral assessments Central nervous system Data interpretation Dopamine systems Genetic manipulations Imaging techniques Motor dysfunction

Editors and affiliations

  • Emma L. Lane
    • 1
  • Stephen B. Dunnett
    • 2
  1. 1., Welsh School of PharmacologyCardiff UniversityCardiffUnited Kingdom
  2. 2.School of Biosciences, Brain Repair GroupCardiff UniversityCardiffUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-297-7
  • Online ISBN 978-1-61779-298-4
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site