Cancer Stem Cells in Solid Tumors

  • Alison L. Allan

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introduction to Cancer Stem Cells

    1. Front Matter
      Pages 1-1
  3. Cancer Stem Cells in Solid Tumors

    1. Front Matter
      Pages 13-13
    2. Jenny E. Chu, Alison L. Allan
      Pages 15-36
    3. Xin Wang, Chitra Venugopal, Sheila K. Singh
      Pages 37-56
    4. Mauro Biffoni, Eros Fabrizi, Lucia Ricci-Vitiani
      Pages 57-78
    5. Jorge Dorado, Alicia G. Serrano, Christopher Heeschen
      Pages 79-97
    6. Paula Kroon, Davide Pellacani, Fiona M. Frame, Norman J. Maitland, Anne T. Collins
      Pages 99-116
    7. Ping Jin, Qiuzhen Liu, Marianna Sabatino, David F. Stroncek, Francesco M. Marincola, Ena Wang
      Pages 117-138
    8. Jun Shen, Feng Jiang
      Pages 139-150
    9. Fang Fang, Curt Balch, Meng Li, Jay M. Pilrose, Kenneth P. Nephew
      Pages 151-176
    10. Russell C. Langan, Itzhak Avital
      Pages 177-195
    11. Mark E. P. Prince, Samantha J. Davis
      Pages 197-205
  4. Cancer Stem Cell Gene Expression and Mechanisms: Convergence of Embryonic and Tumorigenic Signaling Pathways

    1. Front Matter
      Pages 207-207
    2. Daniela Quail, Meghan Taylor, Michael Jewer, Lynne-Marie Postovit
      Pages 223-242
  5. Model Systems for Studying Cancer Stem Cell Biology and Therapeutic Development

    1. Front Matter
      Pages 257-257
    2. Viviana Anelli, Cristina Santoriello, Marina C. Mione
      Pages 283-296
    3. Paula Foster
      Pages 297-309
  6. Clinical and Therapeutic Implications of Cancer Stem Cells

    1. Front Matter
      Pages 327-327
    2. Zeshaan A. Rasheed, Jeanne Kowalski, William H. Matsui
      Pages 329-343
    3. Cleo Y-F Lee, Maximilian Diehn
      Pages 345-360
    4. Vera S. Donnenberg, Ludovic Zimmerlin, Albert D. Donnenberg
      Pages 361-379
    5. Ciara S. O’Brien, Sacha J. Howell, Gillian Farnie, Robert B. Clarke
      Pages 381-402
    6. Alysha K. Croker, Alison L. Allan
      Pages 403-429
  7. Final Thoughts

    1. Front Matter
      Pages 431-431
    2. Craig Gedye, Richard P. Hill, Laurie Ailles
      Pages 433-464
  8. Back Matter
    Pages 465-475

About this book


The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs.


Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.


Topics covered include:

  • Introduction of the CSC hypothesis
  • Historical perspectives and the contributing lessons from leukemia
  • Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer
  • Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways
  • In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs
  • The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance
  • Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field


This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.


Allan Cancer Cell Solid Stem Tumor

Editors and affiliations

  • Alison L. Allan
    • 1
  1. 1.Dept. Oncology & Anatomy & Cell BiologyUniversity of Western OntarioLondonCanada

Bibliographic information