Nuclear Reprogramming and Stem Cells

  • Justin Ainscough
  • Shinya Yamanaka
  • Takashi Tada

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xv
  2. John Gurdon, Azim Surani
    Pages 1-2
  3. Ai Khim Lim, Barbara B. Knowles, Toshie Kai, Daniel M. Messerschmidt
    Pages 7-24
  4. Ramiro Alberio, Andrew D. Johnson
    Pages 45-57
  5. Kunio Hirano, Takashi Tada
    Pages 59-69
  6. Nicholas Mullin, Ian Chambers
    Pages 99-112
  7. Shinji Masui
    Pages 113-125
  8. Takuya Shimazaki, Hideyuki Okano
    Pages 127-140
  9. Sowmya Parameswaran, Sudha Balasubramanian, Iqbal Ahmad
    Pages 141-153
  10. Fumitaka Osakada, Masayo Takahashi
    Pages 155-175
  11. Kevin Docherty
    Pages 177-191
  12. Christopher Rao, Nadire N. Ali, Thanos Athanasiou, Cesare Terracciano, Sian Harding
    Pages 217-238
  13. Takamichi Miyazaki, Hirofumi Suemori
    Pages 251-264
  14. Neil J. Harrison, Duncan Baker, Peter W. Andrews
    Pages 265-276

About this book

Introduction

Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of targeted and personalized therapeutic applications that many considered, until recently, to be nothing more that a far fetched dream. This volume provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years.

 

Since the early 1950s a small number of notable experiments have provided significant impetus to the field, primarily the demonstration of reprogramming ability, first by the complex cytoplasmic milieu that constitutes the amphibian egg, then that of the mammalian egg, and finally that of the mammalian embryonic stem cell. Most recently, the demonstration that a limited pool of defined molecules is capable of reprogramming a multitude of cell types has provided massive impetus and facilitated transition towards realistic therapeutic application. We have therefore reproduced some of the key articles that elegantly document these dramatic stages of development of the field in an inclusive appendix to the book, for the benefit of readers keen to investigate the history of how the field of stem cell biology has evolved.

 

Owing to the ever broadening nature of this field, and the incredible rate at which it is evolving, the main content of this volume focuses on areas that have shown significant movement in recent years, are most likely to translate into personalized therapeutic application, and thus provide greatest potential for significant impact on human health in the not too distant future. We recognize that research into many other disease states and cell types are all equally worthy of discussion. We would therefore like to acknowledge those researchers involved whose work we have not been able to include in this volume. Nuclear Reprogramming and Stem Cells will serve as a valuable resource for all researchers in the field of stem cell biology, including those just setting out on their career path as well as those already established in the field.

Keywords

Ainscough Cell Nuclear Reprogramming Stem Tada Yamanaka

Editors and affiliations

  • Justin Ainscough
    • 1
  • Shinya Yamanaka
    • 2
  • Takashi Tada
    • 3
  1. 1.Leeds Institute of Genetics,, Health & TherapeuticsUniversity of LeedsLeedsUnited Kingdom
  2. 2.Inst. Frontier Medical SciencesKyoto UniversityKyotoJapan
  3. 3.Inst. Frontier Medical SciencesKyoto UniversityKyotoJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-61779-225-0
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-61779-224-3
  • Online ISBN 978-1-61779-225-0
  • About this book