Adult Stem Cells

Biology and Methods of Analysis

  • Donald G.¬†Phinney

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Basic Biology of Adult Stem Cells

    1. Front Matter
      Pages 1-1
    2. Yoshiko Matsumoto, Hiroko Iwasaki, Toshio Suda
      Pages 35-55
    3. Jessica M. Shookhoff, G. Ian Gallicano
      Pages 57-94
    4. Antonio Lo Nigro, Philip Roelandt, Catherine M. Verfaillie
      Pages 95-112
    5. Eva Mezey
      Pages 113-131
  3. Characterization of Adult Stem Cells

    1. Front Matter
      Pages 133-133
    2. Kurtis T. Sobush, Keitaro Matsumoto, Huaiyong Chen, Barry R. Stripp
      Pages 135-161
    3. Loic P. Deleyrolle, Brent A. Reynolds, Florian A. Siebzehnrubl
      Pages 163-179
    4. Naomi J. Guppy, Linda J. Nicholson, Malcolm R. Alison
      Pages 181-199
  4. Regulation of Life Span and Immortalization

    1. Front Matter
      Pages 201-201
    2. Philip Davy, Rich Allsopp
      Pages 203-223
    3. Christine E. Eyler, John M. Heddleston, Masahiro Hitomi, Olga A. Guryanova, Jennifer M. Macswords, William A. Flavahan et al.
      Pages 225-248
  5. Back Matter
    Pages 249-279

About this book

Introduction

This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells, while it also describes and critically evaluates the methods currently used to assess stem cell self-renewal. The chapters also seek to distinguish this process from other aspects of cell survival, such as the regulation of life span, senescence, and immortalization at a molecular level.

The monograph begins with a section that examine the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up. The second section details in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem cell paradigm, and considers the function of ABC transporters and aldehyde dehydrogenase in adult stem-cell biology. The final section shifts the focus to the life-span regulation and immortalization and features a chapter on the cancer stem cell paradigm.

This is an authoritative volume on one of the frontiers of genetic research, and will serve as a valuable resource, not just for established scientists but also for those now entering the field of stem cell biology.

Keywords

Stem Cells adult stem cell biology miRNA pluripotency genes

Editors and affiliations

  • Donald G.¬†Phinney
    • 1
  1. 1., Department of Molecular TherapeuticsThe Scripps Research InstituteJupiterUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-61779-002-7
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-61779-001-0
  • Online ISBN 978-1-61779-002-7
  • About this book