Table of contents

  1. Front Matter
    Pages i-xv
  2. Erika L. Abel, John DiGiovanni
    Pages 27-51
  3. Stephen S. Hecht
    Pages 53-74
  4. John D. Groopman, Gerald N. Wogan
    Pages 113-133
  5. Trevor M. Penning
    Pages 135-158
  6. Melinda S. Yates, Thomas W. Kensler
    Pages 159-179
  7. Suse Broyde, Lihua Wang, Yuqin Cai, Lei Jia, Robert Shapiro, Dinshaw J. Patel et al.
    Pages 181-207
  8. Seon Hwa Lee, Ian A. Blair
    Pages 227-244
  9. Agus Darwanto, Jonathan D. Van Ornam, Victoria Valinluck Lao, Lawrence C. Sowers
    Pages 245-266
  10. Ye Peng, Hong Wang, Lucas Santana-Santos, Caroline Kisker, Bennett Van Houten
    Pages 267-296
  11. Anthony E. Pegg, Sreenivas Kanugula, Natalia A. Loktionova
    Pages 321-343
  12. Jeong-Yun Choi, Robert L. Eoff, F. Peter Guengerich
    Pages 345-373
  13. Zahidur Abedin, Sushmita Sen, Elise Morocco, Jeffrey Field
    Pages 401-422
  14. Back Matter
    Pages 423-440

About this book

Introduction

This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.

Keywords

Cancer Cancer Research Carcinogenesis Chemical

Editors and affiliations

  • Trevor M. Penning
    • 1
  1. 1.School of Medicine, Dept. PharmacologyUniversity of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-61737-995-6
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-61737-994-9
  • Online ISBN 978-1-61737-995-6
  • About this book