The Opiate Receptors

  • Gavril W. Pasternak

Part of the The Receptors book series (REC)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Historical Perspectives

    1. Front Matter
      Pages 1-1
    2. Christopher J. Evans, Donna L. Hammond, Robert C. A. Frederickson
      Pages 23-71
  3. Characterization of Opioid Receptor Binding Sites

    1. Front Matter
      Pages 73-73
    2. Gavril W. Pasternak
      Pages 75-93
    3. Yossef Itzhak
      Pages 95-142
    4. R. Suzanne Zukin, Stephen R. Zukin
      Pages 143-163
    5. Eric J. Simon, Jacob M. Hiller
      Pages 165-194
  4. Location of Opioid Receptors

    1. Front Matter
      Pages 195-195
    2. Robert R. Goodman, Benjamin A. Adler, Gavril W. Pasternak
      Pages 197-228
  5. Mechanisms of Receptor Action

    1. Front Matter
      Pages 229-229
    2. Steven R. Childers
      Pages 231-271
    3. Charles Chavkin
      Pages 273-303
  6. Pharmacological Correlation of Binding Sites with Function

    1. Front Matter
      Pages 305-305
    2. Paul L. Wood, Smriti Iyengar
      Pages 307-356
  7. Regulation of Opioid Receptors

    1. Front Matter
      Pages 423-423
    2. Steven G. Blanchard, Kwen-Jen Chang
      Pages 425-439
    3. Andrew P. Smith, Ping-Yee Law, Horace H. Loh
      Pages 441-485
  8. Future Vistas

    1. Front Matter
      Pages 487-487
  9. Back Matter
    Pages 497-499

About this book


The growth of the opiate field over the past decade has been enor­ mous. Initial interest focused upon the strategic clinical impor­ tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi­ gators in almost all areas of neuroscience as well as pharmacol­ ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have emerged and been settled; others remain. Early studies must now be inter­ preted on the basis of current information. Thousands of papers examining various aspects of opiates and the endogenous opioids present separate pieces of a large puzzle. The goal of this volume is to put the pieces together to give a coherent overview of opiate receptor pharmacology and to provide insights into both the mo­ lecular and classical pharmacology of opiates and the opioid pep­ tides. The issue of multiple classes of opiate and opioid peptide re­ ceptors and their importance in understanding mechanisms of ac­ tion provides the major focus of the book. The study of opiates and opioid peptides provides a unique research opportunity in the neuropharmacology of drug receptors.


brain drug endogenous opioid peptides neuropharmacology neuroscience opioid receptor research

Editors and affiliations

  • Gavril W. Pasternak
    • 1
  1. 1.Memorial Sloan-Kettering Cancer Center and Cornell University Medical CollegeNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1988
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-6768-1
  • Online ISBN 978-1-60761-990-1
  • Series Print ISSN 1048-6909
  • Series Online ISSN 2524-6488
  • Buy this book on publisher's site