5-HT2C Receptors in the Pathophysiology of CNS Disease

  • Giuseppe Di Giovanni
  • Ennio Esposito
  • Vincenzo Di Matteo

Part of the The Receptors book series (REC, volume 22)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Jose M. Palacios, Angel Pazos, Daniel Hoyer
    Pages 1-16
  3. Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Francesco Berardi, Roberto Perrone
    Pages 29-50
  4. Maria N. Garnovskaya, John R. Raymond
    Pages 75-96
  5. Nicolas Renault, Amaury Farce, Philippe Chavatte
    Pages 97-127
  6. Katharine Herrick-Davis, Dinah T. Farrington
    Pages 129-155
  7. Kazuya Iwamoto, Miki Bundo, Tadafumi Kato
    Pages 157-167
  8. Eliyahu Dremencov, Joost H. A. Folgering, Sandra Hogg, Laurence Tecott, Thomas I. F. H. Cremers
    Pages 249-260
  9. Fabio Panariello, Naima Javaid, Vincenzo De Luca
    Pages 261-274
  10. Herbert Y. Meltzer, Liwen Sun, Hitoshi Hashimoto
    Pages 275-291
  11. Paul J. Fletcher, Guy A. Higgins
    Pages 293-324
  12. Philippe De Deurwaerdère, Laurence Mignon, Marie-Françoise Chesselet
    Pages 351-382
  13. Jaime M. Monti, Héctor Jantos
    Pages 393-412
  14. Rita Jakus, Gyorgy Bagdy
    Pages 429-444
  15. López-Vázquez Miguel Ángel, Gutiérrez-Guzmán Blanca Érika, Cervantes Miguel, Olvera-Cortés María Esther
    Pages 461-507
  16. Back Matter
    Pages 545-557

About this book


Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor research has grown so fruitful, given that it is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of numerous behaviors. It has further been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of central nervous system disorders. The time, therefore, is more than appropriate to offer the first ever overview of the research of 5-HT2c receptors. Part of the popular and important series, “The Receptors,” The 5-HT2c Receptor provides a thorough update of the functional status of the 5-HT2c receptor. It covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor so as to highlight its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. In addition, the book investigates the receptors’ therapeutic potential in a range of different diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy. While not exhaustive, this text is a vital tool in understanding the past and inspiring the future of interdisciplinary research on the 5-HT2c receptor.

Editors and affiliations

  • Giuseppe Di Giovanni
    • 1
  • Ennio Esposito
    • 2
  • Vincenzo Di Matteo
    • 3
  1. 1., Department of Physiology and BiochemistrUniversity of MaltaMaltaItaly
  2. 2.Centro di Ricerche Farmacologiche e, BiomedicheConsorzio Mario Negri SudSanta Maria ImbaroItaly
  3. 3.Centro di Ricerche Farmacologiche e, BiomedicheConsorzio Mario Negri SudSanta Maria ImbaroItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-60761-940-6
  • Online ISBN 978-1-60761-941-3
  • Series Print ISSN 1048-6909
  • Series Online ISSN 2524-6488
  • Buy this book on publisher's site