Bladder Tumors:

Molecular Aspects and Clinical Management

  • Vinata B. Lokeshwar
  • Axel S. Merseburger
  • Stefan H. Hautmann

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Maria J. Ribal
    Pages 1-22
  3. Diogo O. Escudero, Samir P. Shirodkar, Vinata B. Lokeshwar
    Pages 23-41
  4. Arndt Hartmann, Simone Bertz
    Pages 43-61
  5. M. Ploeg, J. A. Witjes
    Pages 63-77
  6. Eva M. Wojcik
    Pages 79-90
  7. Brian K. McNeil, Obi O. Ekwenna, Robert H. Getzenberg
    Pages 91-119
  8. Joshua Sleeper, Yair Lotan
    Pages 121-137
  9. Tomonori Habuchi
    Pages 139-163
  10. Steven Christopher Smith, Dan Theodorescu
    Pages 165-191
  11. David A. Levy, J. Stephen Jones
    Pages 193-215
  12. Willem Oosterlinck
    Pages 217-236
  13. Satya Allaparthi, K. C. Balaji
    Pages 237-252
  14. Kishore Thekke Adiyat, Devendar Katkoori, Mark S. Soloway
    Pages 253-270
  15. John H. Bishay, Eugene S. Park, George P. Hemstreet
    Pages 271-295
  16. Sandra Waalkes, Axel S. Merseburger, Markus A. Kuczyk
    Pages 297-310
  17. Juergen E. Gschwend
    Pages 311-330
  18. Richard E. Hautmann, Stefan H. Hautmann
    Pages 331-363
  19. Amir Sherif
    Pages 377-386
  20. Mesut Remzi, Matthias Waldert
    Pages 387-407
  21. Maria De Santis, Mark Bachner
    Pages 409-431
  22. Hassan Abol-Enein, Bruce R. Kava, Adrienne J. K. Carmack
    Pages 433-456
  23. Back Matter
    Pages 457-466

About this book


Clinical management of bladder cancer is challenging of the heterogeneity among bladder tumors with respect to invasion and metastasis, and frequent occurrence of new tumors in the bladder among patients treated with bladder preservation treatments. Treatment of bladder cancer spans from tumor resection and intravesical treatment, to neoadjuvant chemotherapy, radical surgery and adjuvant chemotherapy. At the same time, bladder cancer is also at the forefront of biomarker development because of the ease of developing noninvasive urine tests. The features of environment-driven carcinogenesis and divergent molecular pathways in the development of low- and high-grade tumors provide a unique opportunity for advance molecular research in cancer biology. Bladder Tumors: Molecular Aspects and Clinical Management is a collection of comprehensive reviews on the state-of-the art basic science research and clinical management of bladder cancer. The book progresses from epidemiology of bladder cancer, molecular basis of bladder carcinogenesis, to standard and molecular aspects of bladder cancer diagnosis and prognosis, and also includes various treatment aspects of both non muscle invasive and muscle invasive bladder cancer. The book features: • Epidemiology, bladder carcinogenesis and divergent molecular pathways of bladder cancer development. • Pathology of bladder tumors, cystoscopy, cytology and newer techniques of bladder cancer diagnosis. • Molecular basis, efficacy and economics of diagnostic and prognostic markers for bladder cancer, with an added feature of recent inventions of molecular nomongrams. • Clinical management of low-grade and non muscle invasive bladder tumors. • Intravesical chemotherapy versus immune (BCG) therapy. • Clinical management of patients with muscle invasive bladder cancer, including neoadjuvant therapy, various aspects of cystectomy including urinary diversion and recent advances such as laproscopic cystectomy • Adjuvant chemotherapy for metastatic bladder cancer and management of upper track tumors • Non-transitional cell carcinoma tumors. The book is truly an international effort to bring the latest development in bladder cancer to the readers. The contributing authors, leaders in their respective areas of expertise-related to bladder cancer, were assembled from different parts of the world. Since the editorial team of the book consists of a translational researcher (Vinata B. Lokeshwar) and practicing urologists with expertise in clinical research (Stefan Hautmann and Axel S. Merseburger), it the Editors’ intent to promote an ongoing dialog among researchers and urologists to help reduce morbidity, mortality associated with bladder cancer, while improving the quality of life for patients.


Bladder Cancer Research Tumors

Editors and affiliations

  • Vinata B. Lokeshwar
    • 1
  • Axel S. Merseburger
    • 2
  • Stefan H. Hautmann
    • 3
  1. 1.Miller School of Medicine, Dept. Urology & Cell Biology & AnatomyUniversity of MiamiMiamiUSA
  2. 2., Department of Urology and Urologic OncolHannover Medical SchoolHannoverGermany
  3. 3.Klinik für Urologie und KinderurologieUniversitätsklinikum Schleswig-HolsteinKielGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60761-927-7
  • Online ISBN 978-1-60761-928-4
  • Buy this book on publisher's site