Studies on Renal Disorders

  • Toshio Miyata
  • Kai-Uwe Eckardt
  • Masaomi Nangaku

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Oxidative Stress

  3. Clinical Aspects of Oxidative Stress in the Kidney

    1. Front Matter
      Pages 119-119
    2. Bernardo Rodriguez-Iturbe, Nosratola D. Vaziri
      Pages 121-142
    3. Yuri Y. Sautin, Witcha Imaram, Kyung Mee Kim, Alexander Angerhofer, George Henderson, Richard Johnson
      Pages 143-159
    4. Sara Terryn, Olivier Devuyst
      Pages 179-203
    5. Abolfazl Zarjou, József Balla, György Balla, Anupam Agarwal
      Pages 205-228
    6. Samuel N. Heyman, Seymour Rosen, Mogher Khamaisi, Jean-Marc Odee, Christian Rosenberger
      Pages 229-256
    7. Chih-Wei Yang
      Pages 293-304
    8. Takefumi Mori, Toshio Miyata, Sadayoshi Ito
      Pages 305-320
  4. Current Therapy Targeting Oxidative tress

    1. Front Matter
      Pages 321-321
    2. Josephine M. Forbes, Mark E. Cooper
      Pages 323-335

About this book

Introduction

Conditions such as oxidative stress and hypoxia, which have a generalized impact on the oxygen metabolism, have been implicated in the genesis of kidney disease. This means that deepening our understanding of the pathobiology of oxygen metabolism in such diseases could be a fruitful path towards tangible clinical benefits. Studies in Renal Disorder collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances. The causal role of impaired oxygen metabolism in kidney disease has numerous clinical implications. It affects our understanding of the therapeutic benefits accruing from anti-hypertensive agents; the way we control hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of dietary approaches to the correction of obesity. The defensive mechanisms against oxidative stress, such as the Nrf2-Keap1 system, and hypoxia, such as the PHD-HIF system, have recently been explored in various cells, including kidney cells. These mechanisms include intracellular sensors for oxidative stress and hypoxia. This means that novel approaches targeting these sensors may offer clinical benefits in kidney disease in which oxidative stress and/or hypoxia is a final, common pathway.

Keywords

hypoxia kidney disease nitrosative stress oxidative stress oxygen metabolism

Editors and affiliations

  • Toshio Miyata
    • 1
  • Kai-Uwe Eckardt
    • 2
  • Masaomi Nangaku
    • 3
  1. 1.Graduate School of Medicine, Division of Molecular Medicine and TheraTohoku UniversitySendaiJapan
  2. 2.Medizinische Klinik IVUniversitätsklinikum ErlangenErlangenGermany
  3. 3.Graduate School of Medicine &, Faculty of MedicineUniversity of TokyoTokyoJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-857-7
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-60761-856-0
  • Online ISBN 978-1-60761-857-7
  • About this book