Table of contents

  1. Front Matter
    Pages i-x
  2. Working with AD- and FTD-Related Molecules

  3. Working with AD- and FTD-Related Molecules

    1. Front Matter
      Pages 11-11
    2. W. Blaine Stine, Lisa Jungbauer, Chunjiang Yu, Mary Jo LaDu
      Pages 13-32
    3. Ganesh M. Shankar, Alfred T. Welzel, Jessica M. McDonald, Dennis J. Selkoe, Dominic M. Walsh
      Pages 33-44
    4. Mathew A. Sherman, Sylvain E. Lesné
      Pages 45-56
    5. Luke A. Esposito
      Pages 71-84
    6. Sanjay W. Pimplikar, Anupama Suryanarayana
      Pages 85-91
    7. Umesh K. Jinwal, Chad A. Dickey
      Pages 93-108
    8. Wanjoo Chun, Geoffrey S. Waldo, Gail V. W. Johnson
      Pages 109-123
    9. Yvonne Newhouse, Karl H. Weisgraber
      Pages 127-140
  4. Model Systems and Outcome Measures

  5. Back Matter
    Pages 275-277

About this book


Alzheimer’s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent years have spurred new research approaches to these conditions. In Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols, expert investigators bring together the many divergent areas of expertise used to study these diseases, including behavior, electrophysiology, confocal microscopy, and hardcore biochemistry. Beginning with an overview of the two diseases and contemporary research on them, the book continues with specialized protocols for working with amyloid-β peptide, tau, and apolipoprotein E as well as experimental systems for studying AD and FTD, including cell and animal models, and outcome measures that can be used to assess neuronal function in these systems. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols serves as an ideal guide for all scientists pursuing the cause and cure of these widespread and nightmarishly debilitating disorders.


Amyloid-β peptide & apolipoprotein E Cell and animal models Genetic risk factors Molecular neuropathology Neurodegenerative disorder Neuronal dysfunction Pathobiochemistry

Editors and affiliations

  • Erik D. Roberson
    • 1
  1. 1.Ctr. Neurodegeneration & Experimental Th, Depts. of Neurology and NeurobiologyUniversity of Alabama at BirminghamBirminghamUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-743-3
  • Online ISBN 978-1-60761-744-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site