Aging and Age-Related Disorders

  • Stephen Bondy
  • Kenneth Maiese
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Table of contents

  1. Front Matter
    Pages i-xv
  2. General Aspects of Aging

    1. Front Matter
      Pages 1-1
    2. Predrag Ljubuncic, Einat Gochman, Abraham Z. Reznick
      Pages 27-54
    3. Ravichandran Ramasamy, Loredana G. Bucciarelli, Shi Fang Yan, Ann Marie Schmidt
      Pages 79-90
    4. Edward H. Sharman
      Pages 91-117
    5. Jose Viña, Consuelo Borrás, Mari Carmen Gómez-Cabrera, Juan Gambini, Raul López-Grueso, Federico V. Pallardó
      Pages 119-128
    6. Shi-Bei Wu, Yu-Ting Wu, Chih-Hao Wang, Wan-Yu Lee, Yau-Huei Wei
      Pages 129-148
    7. Miklós Péter Kalapos, Kaushik M. Desai, Lingyun Wu
      Pages 149-167
  3. The Cardiovascular System

    1. Front Matter
      Pages 169-169
    2. Kenneth Maiese, Zhao Zhong Chong, Jinling Hou, Yan Chen Shang
      Pages 170-208
    3. Isabelle Gorenne, Martin R. Bennett
      Pages 211-235
    4. Andreas Daiber, Joachim Kienhoefer, Rebecca Zee, Philip Wenzel, Volker Ullrich, Bernd Loo et al.
      Pages 237-257
    5. Yi Shi, Giovanni G. Camici, Thomas F. Lüscher
      Pages 259-275
    6. G. Riccioni, V. Sblendorio, N. D’Orazio
      Pages 277-296
    7. Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita, Ryozo Nagai
      Pages 297-307
    8. Nathalie Thorin-Trescases, Eric Thorin
      Pages 309-321
    9. Julio Sartori Valinotti, Licy Yanes, Jane F. Reckelhoff
      Pages 323-336
  4. The Nervous System

    1. Front Matter
      Pages 337-337

About this book

Introduction

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

Keywords

Aging, Oxidative Stress, Neurology Alzheimer Regulation age cells development influence

Editors and affiliations

  • Stephen Bondy
    • 1
  • Kenneth Maiese
    • 2
  1. 1.Center for Occupational & Environmental, Department of MedicineUniversity of California, IrvineIrvineUSA
  2. 2.New Jersey Medical School, Department of Neurology and NeuroscienceUniversity of Medicine & Dentistry of NeNewarkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-602-3
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-60761-601-6
  • Online ISBN 978-1-60761-602-3
  • About this book