Protein Kinase C in Cancer Signaling and Therapy

  • Marcelo G. Kazanietz

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Regulation of PKC Isozyme Function: From Genes to Biochemistry

    1. Front Matter
      Pages 1-1
    2. Peter M. Blumberg, Noemi Kedei, Nancy E. Lewin, Dazhi Yang, Juan Tao, Andrea Telek et al.
      Pages 25-53
    3. Isabel Mérida, Silvia Carrasco, Antonia Avila-Flores
      Pages 55-78
    4. Jeewon Kim, Daria Mochly-Rosen
      Pages 79-103
  3. PKC Isozymes in the Control of Cell Function

    1. Front Matter
      Pages 106-106
    2. Gry Kalstad Lønne, Christer Larsson
      Pages 107-115
    3. Jennifer D. Black
      Pages 155-188
    4. Mary E. Reyland, Andrew P. Bradford
      Pages 189-222
    5. Maria T. Diaz-Meco, Jorge Moscat
      Pages 223-244
  4. PKC Isozymes in Cancer

About this book

Introduction

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents.

Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. It is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.

Protein Kinase C in Cancer Signaling and Therapy is composed of twenty-three chapters written by leading experts in the field. The book is divided into four sections: Regulation of PKC isozyme function: from genes to biochemistry, PKC isozymes in the control of cell function, PKC isozymes in cancer, and PKC isozymes as targets for cancer therapy. Each section of Protein Kinase C in Cancer Signaling and Therapy begins with an introduction by an established professional in the field of Protein kinase C, followed by chapters that elucidate the importance of PKC in current cancer research.

Keywords

DNA apoptosis cancer cancer research cancer therapy carcinogenesis carcinoma cell inflammation melanoma metastasis mutagen prostate cancer research tumor

Editors and affiliations

  • Marcelo G. Kazanietz
    • 1
  1. 1.School of MedicineUniversity of PennsylvaniaPhiladeliphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-543-9
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Medicine
  • Print ISBN 978-1-60761-542-2
  • Online ISBN 978-1-60761-543-9
  • About this book