Pharmacogenomic Testing in Current Clinical Practice

Implementation in the Clinical Laboratory

  • Alan H. B. Wu
  • Kiang-Teck J. Yeo

Part of the Molecular and Translational Medicine book series (MOLEMED)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Basic Concepts

    1. Front Matter
      Pages 1-1
    2. Kiang-Teck J. Yeo, Nikolina Babic, Alan H. B. Wu
      Pages 3-14
    3. Nikolina Babic, Loren J. Joseph, Kiang-Teck J. Yeo
      Pages 15-34
    4. Steven H. Y. Wong, Christopher Happy, Daniel Blinka, Suson Goch, Jeffrey M. Jensen, Joseph M. Donald et al.
      Pages 47-56
  3. Chemotherapeutics

    1. Front Matter
      Pages 57-57
    2. R. Stephanie Huang, Federico Innocenti, Mark J. Ratain
      Pages 59-75
    3. Christine L. H. Snozek, Alicia Algeciras-Schimnich, Matthew P. Goetz, Loralie J. Langman
      Pages 77-89
    4. Terreia S. Jones, Mary V. Relling
      Pages 91-114
  4. Specific Pharmacogenomic Targets: Cardiovascular Drugs

    1. Front Matter
      Pages 115-115
    2. Janice Y. Chyou, Marc S. Sabatine
      Pages 139-153
    3. Richard L. Seip, Jorge Duconge, Gualberto Ruaño
      Pages 155-174
    4. H. Robert Superko, Tom White, James Forrester, Spencer King III
      Pages 175-198
  5. Drugs that Cause Delayed Hypersensitivity

    1. Front Matter
      Pages 199-199
    2. Elizabeth J. Phillips, Simon A. Mallal
      Pages 201-212
    3. Pei Chen, Shuen-Iu Hung, Shih-Yang Chen, Yuan-Tsong Chen
      Pages 213-223
    4. Shuen-Iu Hung, Wen-Hung Chung, Jing-Jane Tsai, Yuan-Tsong Chen
      Pages 225-236
  6. Miscellaneous Drugs

    1. Front Matter
      Pages 237-237

About this book

Introduction

While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field.

Keywords

Clinical Pharmacogenomics Irinotecan Molecular Medicine Personalized Medicine Tamoxefin Translational Medicine

Editors and affiliations

  • Alan H. B. Wu
    • 1
  • Kiang-Teck J. Yeo
    • 2
  1. 1.San Francisco General Hospital, Clinical Chemistry Lab.University of California, San FranciscoSan FranciscoUSA
  2. 2.Department of Pathology, Clinical Pharmacogenomics ProgramUniversity of ChicagoChicagoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-283-4
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60761-282-7
  • Online ISBN 978-1-60761-283-4
  • About this book