Telomeres and Telomerase in Cancer

Editors:

ISBN: 978-1-60327-306-0 (Print) 978-1-60327-879-9 (Online)

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii

  2. Basic Background

    1. No Access

      Chapter

      Pages 3-21

      Telomeres and Telomerase in Humans

    2. No Access

      Chapter

      Pages 23-46

      Telomere-Binding Proteins in Humans

    3. No Access

      Chapter

      Pages 47-85

      Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms

    4. No Access

      Chapter

      Pages 87-125

      Telomere Dysfunction and the DNA Damage Response

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      Chapter

      Pages 127-148

      Alternative Lengthening of Telomeres in Human Cells

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      Chapter

      Pages 149-167

      Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer

  3. Telomeres and Telomerase in Human Cancers

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      Chapter

      Pages 171-180

      Role of Telomeres and Telomerase in Cancer

    2. No Access

      Chapter

      Pages 181-210

      Diagnostic Value I: Solid Tumors

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      Chapter

      Pages 211-224

      Diagnostic Value II: Hematopoietic Malignancies

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      Chapter

      Pages 225-249

      Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors

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      Chapter

      Pages 251-280

      Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors

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      Chapter

      Pages 281-291

      Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors

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      Chapter

      Pages 293-312

      Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer

  4. Experimental Protocols

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      Chapter

      Pages 315-335

      Protocol I: Telomerase Activity and Telomerase Expression

    2. No Access

      Chapter

      Pages 337-350

      Protocol II: Importance and Methods of Telomere G-Tail Length Quantification

    3. No Access

      Chapter

      Pages 351-364

      Protocol III: Detection of Alternative Lengthening of Telomeres

  5. Back Matter

    Pages 365-373