Tumor Biomarker Discovery

Methods and Protocols

  • Michael A. Tainsky

Part of the Methods in Molecular Biology book series (MIMB, volume 520)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Sacha Gnjatic, Lloyd J. Old, Yao-Tseng Chen
    Pages 11-19
  3. Madhumita Chatterjee, Jerzy Wojciechowski, Michael A. Tainsky
    Pages 21-38
  4. Songming Chen, Brian B. Haab
    Pages 39-58
  5. Mary Ann Comunale, Anand Mehta
    Pages 59-74
  6. Virginia Espina, Lance A. Liotta, Emanuel F. Petricoin III
    Pages 89-105
  7. Brian L. Hood, David E. Malehorn, Thomas P. Conrads, William L. Bigbee
    Pages 107-128
  8. Shannon L. Servoss, Rachel Gonzalez, Susan Varnum, Richard C. Zangar
    Pages 143-150
  9. Christopher B. Moeder, Jennifer M. Giltnane, Sharon Pozner Moulis, David L. Rimm
    Pages 163-175
  10. Maureen T. Cronin, Debjani Dutta, Mylan Pho, Anhthu Nguyen, Jennie Jeong, Mei-lan Liu
    Pages 177-193
  11. Lisa M. Farwell, Victoria A. Joshi
    Pages 205-220
  12. Takeshi Nakamura, Eiji Sunami, Tuny Nguyen, Dave S.B. Hoon
    Pages 221-229
  13. Shilong Zhong, Marjorie Romkes
    Pages 231-245
  14. Michele L. Cote
    Pages 247-257
  15. Adi Laurentiu Tarca, Sorin Draghici, Roberto Romero
    Pages 259-272
  16. Natalie J. Serkova, Kristine Glunde
    Pages 273-295
  17. Bob L. Hou, Jiani Hu
    Pages 297-314
  18. Natalie J. Serkova, Kendra M. Hasebroock, Susan L. Kraft
    Pages 315-327
  19. Back Matter
    Pages 329-332

About this book


Through a variety of mechanisms, cancer cells provide the biomarker material that can lead to their own detection, which then grants clinicians the opportunity for non-invasive body fluid and tissue analysis able to indicate the presence of tumors or the level of tumor burden.  In Tumor Biomarker Discovery: Methods and Protocols, experts in the field present detailed chapters focused on the use and development of panels of biomarker analytes while covering subjects such as nucleic acids and protein-based technologies, metabolic profiling by analytic means or spectroscopy, as well as study designs for biomarker discovery and validation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials or reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Cutting-edge and authoritative, Tumor Biomarker Discovery: Methods and Protocols is an ideal guide to the technologies that can be used to discover and validate tumor biomarker panels suitable for the presymptomatic early detection of cancer.


2D liquid chromatography Antigen Biomarker analyte panels Cancer detection Human immune system Laboratory Magnetic resonance spectroscopy Mass spectroscopy Protein microarrays tissue

Editors and affiliations

  • Michael A. Tainsky
    • 1
  1. 1.School of Medicine Wayne State UniversityDetroitU.S.A.

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60327-810-2
  • Online ISBN 978-1-60327-811-9
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site