© 2009

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Molecular Mechanisms and Clinical Applications

  • Andrea Bonetti
  • Roberto Leone
  • Franco M. Muggia
  • Stephen B. Howell

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Novel Platinum Analogues, Original Formulations and Other Heavy Metals

    1. Fazlul Huq, Jun Qing Yu, Philip Beale
      Pages 11-17
    2. Elena Monti, Marzia B. Gariboldi, Raffaella Ravizza, Roberta Molteni, Elisabetta Gabano, Katia Sparnacci et al.
      Pages 19-25
    3. Irene H.L. Hamelers, Anton I.P.M. de Kroon
      Pages 27-32
    4. Maria Serova, Aïda Ghoul, Keyvan Rezaï, François Lokiec, Esteban Cvitkovic, David Nowotnik et al.
      Pages 41-47
    5. Roberta Bertani, Silvia Mazzega Sbovata, Valentina Gandin, Rino A. Michelin, Cristina Marzano
      Pages 49-56
    6. Sabine H. van Rijt, Anna F. A. Peacock, Peter J. Sadler
      Pages 73-79
  3. Cellular Transport and Intracellular Trafficking of Platinum Compounds

    1. Michael M. Gottesman, Matthew D. Hall, Xing-Jie Liang, Ding-Wu Shen
      Pages 83-88
    2. Stephen B. Howell, Roohangiz Safaei
      Pages 89-94
    3. Angelo De Milito, Francesca Luciani, Stefano Fais
      Pages 109-114
    4. Michele Benedetti, Cosimo Ducani, Danilo Migoni, Daniela Antonucci, Vita M. Vecchio, Alessandro Romano et al.
      Pages 125-132
  4. DNA Damage and Signal Transduction: Recognition/Repair And Cell-Response

About this book


The platinum-containing chemotherapeutic agents remain key components of many of the most effective regimens for the treatment of cancer. New information about the chemistry, pharmacology and molecular mechanisms by which these drugs work is leading to both the development of new drugs and more effective use of existing members of this class. Better definition of the genetic basis of malignancies is offering intriguing new insights in to how to use these drugs in a more individualized manner. "Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications", edited by Andrea Bonetti, Steve B. Howell, Roberto Leone, and Franco Muggia, provides succinct summaries of the major new developments in field of platinum drug therapy drawn from presentations made at the 10th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy that took place in Verona, Italy, in December 2007. This meeting, held once every 4 years, brought together the world’s leading investigators working on platinum drugs and their contributions provide a detailed survey of the major research directions in this rapidly evolving field.


Antiproliferative Cancer Chemotherapy Carcinom Cellular Transport DACH-platinum DNA repair Heavy Metal Compounds Pharmacophore Platinum neurotoxicity positron emission tomography

Editors and affiliations

  • Andrea Bonetti
    • 1
  • Roberto Leone
    • 2
  • Franco M. Muggia
    • 3
  • Stephen B. Howell
    • 4
  1. 1.Department of OncologyMater Salutis HospitalLegnagoItaly
  2. 2.Institute of PharmacologyUniversity of VeronaVeronaItaly
  3. 3.Division of Medical OncologyNew York University School of Medicine and the NYU Cancer InstituteNew YorkUSA
  4. 4.Department of Medicine and the Moores Cancer CenterUniversity of CaliforniaSan DiegoUSA

Bibliographic information

  • Book Title Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
  • Book Subtitle Molecular Mechanisms and Clinical Applications
  • Editors Andrea Bonetti
    Roberto Leone
    Franco Muggia
    Stephen B. Howell
  • Series Title Cancer Drug Discovery and Development
  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-60327-458-6
  • Softcover ISBN 978-1-4939-5710-1
  • eBook ISBN 978-1-60327-459-3
  • Edition Number 1
  • Number of Pages XXVI, 398
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site