© 2009

Essentials of Apoptosis

A Guide for Basic and Clinical Research

  • Zheng Dong
  • Xiao-Ming Yin

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Part I. Molecules and Pathways of Apoptosis

    1. Front Matter
      Pages 1-1
    2. Stefan J. Riedl, Fiona L. Scott
      Pages 3-24
    3. Wen-Xing Ding, Xiao-Ming Yin
      Pages 25-61
    4. Eric C. LaCasse, Herman H. Cheung, Allison M. Hunter, Stephanie Plenchette, Douglas J. Mahoney, Robert G. Korneluk
      Pages 63-93
    5. Maria Eugenia Guicciardi, Gregory J. Gores
      Pages 119-150
    6. Silvia Campello, Luca Scorrano
      Pages 151-175
    7. Michael W. Harr, Clark W. Distelhorst
      Pages 177-197
    8. Han-Ming Shen, Shazib Pervaiz
      Pages 199-221
    9. Jonathan L. Coloff, Yuxing Zhao, Jeffrey C. Rathmell
      Pages 223-237
    10. Crissy Dudgeon, Wei Qiu, Quanhong Sun, Lin Zhang, Jian Yu
      Pages 239-260
    11. Carylyn J. Marek, Lars-Peter Erwig
      Pages 261-282
    12. Heinrich Huber, Eric Bullinger, Markus Rehm
      Pages 283-297
  3. Part II: Apoptosis in Model Organisms

    1. Front Matter
      Pages 299-299
    2. Naohide Watanabe, Eric Lam
      Pages 301-324
    3. Didac Carmona-Gutierrez, Frank Madeo
      Pages 325-354
    4. Monica Darland-Ransom, Yi-Chun Wu, Ding Xue
      Pages 355-373
    5. Dianne C. Purves, Jessica P. Monserrate, Carrie Baker Brachmann
      Pages 375-405
  4. Part III. Apoptosis in Mammalian Physiology and Pathogenesis

    1. Front Matter
      Pages 407-407

About this book


As a fundamental biological process, cell death and cell survival is essential to the normal homeostasis of the organism. Our knowledge on this process has been tremendously expanded in the past two decades. Essentials of Apoptosis: A Guide for Basic and Clinical Research was first published in 2003. It timely provided a comprehensive but concise summary of the essential information of apoptosis to both new investigators to the field and seasoned researchers seeking an integrated view of the topics. The past several years have witnessed significant new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. Notable progresses have been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive crosstalk with works in other fields. The second edition incorporates these new developments, in addition to the basic core concepts and machinery of apoptosis. Multiple new topics are added that expand the coverage on different types of cell death (apoptosis, necrosis, autophagic death and mitotic death), and on different death pathways (mediated by mitochondria, endoplasmic reticulum, death receptors, or lysosome). Furthermore, several integrated topics linking cell death to metabolism, redox status, transcription regulation are included and a systems biology approach to study apoptosis is introduced. Moreover, the roles of apoptosis and cell death in the pathogenesis of many human diseases in every major organ system are explored in details with novel therapeutic outlooks. This edition is the result of the hard work by more than 80 leading experts from across the world.

Authoritative, comprehensive and highly instructive, the second edition of Essentials of Apoptosis should be valuable for both novice and seasoned investigators, as an informative reference as well as a practical guide.


Activation Immune System Translation bioinformatics cells mammalian embryos metabolism molecular mechanisms physiology regulation saccharomyces cerevisiae transcription

Editors and affiliations

  • Zheng Dong
  • Xiao-Ming Yin

There are no affiliations available

Bibliographic information


From the reviews of the second edition:

"This book comprehensively reviews knowledge of the main mechanism of cell death, apoptosis, both from the molecular viewpoint and in relation to the roles of this process in mammalian physiology and pathology. … chapters are well written and scholarly in content and present the reader with a thorough and up-to-date insight into these fields. This book is highly recommended for scientists working in many areas of cell or developmental biology, as well as those involved in more clinical fields, such as neurobiology or molecular oncology." (Mike Clemens, Microbiology Today, November, 2009)

“The book ‘Essentials of Apoptosis’ is a collection of 31 review articles, covering a wide variety of approaches in studying cell death. … It enables the reader to get acquainted with many aspects of apoptosis, and impressive amounts of references cited in each of the article allows for further studies on the subject. I recommend this book to anyone seriously interested in research on programmed dell death.” (Piotr P. Stepien, Acta Biochimica Polonica, December, 2010)

“Prof. Yin and Prof. Dong … were able to cover both conceptual and practical aspects as well as both basic and applied research aspects, thus leading to translation research aspects in biomedicine, which is a crucial hot topic in modern biomedical clinic. … the potential readership is made up of the entire scientific comunity … and cellular biologists, developmental biologists, protein scientists.” (CarloAlberto Redi, European Journal of Histochemistry, Vol. 54 (e11), 2010)

“Comprehensive overview of the history and current knowledge of the study of the genetic program of cell death … . the book is to inform the basic researcher and the clinician interested in understanding how inappropriate apoptosis may underlie their area of scientific interest, and in this respect it succeeds. … a welcome addition for the collection of a newcomer to apoptosis: in the basic research lab, a graduate student or post-doc would benefit from … the excellent reference sections provided for each chapter.” (Robert Screaton, The Canadian Journal of Neurological Science, May, 2010)