Oxidative Neural Injury

  • Sigrid C. Veasey

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Kenneth T. Kishida, Eric Klann
    Pages 1-27
  3. Gábor Bánhegyi, Éva Margittai, Miklós Csala, József Mandl
    Pages 45-64
  4. Eitan Okun, Mark P. Mattson
    Pages 83-95
  5. Rosemary H. Milton, Andrey Y. Abramov
    Pages 97-108
  6. Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Hyoung-Gon Lee, Gjumrakch Aliev, Mark A. Smith et al.
    Pages 109-120
  7. Robert B. Petersen, Akihiko Nunomura, Hyoung-gon Lee, Gemma Casadesus, George Perry, Mark A. Smith et al.
    Pages 121-136
  8. Pratap Chand, Irene Litvan
    Pages 159-178
  9. Ramez Wassef, Stefan H. Heinemann, Toshinori Hoshi
    Pages 193-206
  10. Back Matter
    Pages 207-215

About this book

Introduction

Edited by
Sigrid Veasey, M.D.
Center for Sleep and Respiratory Neurobiology
Department of Medicine
University of Pennsylvania

Oxidative changes are observed in healthy aging of the nervous system, neurodegenerative processes and other forms of neural injury. At the same time, reactive oxygen species and reactive nitrogen species play critical roles in rapid response signaling, in learning, plasticity and in neuronal homeostasis. How do reactive oxygen and nitrogen molecules play such divergent roles in physiology and pathophysiology? How do these molecules contribute to neural injury, dysfunction and loss? The text Oxidative Neural Injury brings together international experts to systematically describe the biochemistry of reactive oxygen and nitrogen species signaling and then integrate this biochemistry into the neurobiology of redox in learning and plasticity and in healthy aging. This information will serve as the much-needed infrastructure for understanding in a more comprehensive manner how redox modifications contribute to neurodegenerative processes, in both early and late injury. Indeed, it is apparent that the development of effective therapies for neurodegenerative processes will first require a careful understanding of these critical roles of reactive oxygen and nitrogen molecules in neuronal signaling and cellular homeostasis, and this must be complemented with a comprehensive understanding of how reactive oxygen and nitrogen species perturb specific organelle and cellular functions.

Keywords

Nervous System Neurology Neuroscience Oxidation Parkinson Proteomics Translation biochemistry neurons pathophysiology physiology

Editors and affiliations

  • Sigrid C. Veasey

There are no affiliations available

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60327-342-8
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-60327-341-1
  • Online ISBN 978-1-60327-342-8
  • About this book