Vitamin D

Physiology, Molecular Biology, and Clinical Applications

  • Michael F. Holick

Part of the Nutrition and Health book series (NH)

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Introduction and Basic Biology

    1. Front Matter
      Pages 1-1
    2. Tai C. Chen, Zhiren Lu, Michael F. Holick
      Pages 35-60
    3. Lori A. Plum, Hector F. DeLuca
      Pages 61-97
    4. Diane R. Dowd, Paul N. MacDonald
      Pages 135-152
    5. Julia Barsony
      Pages 153-173
    6. Martin A. Montecino, Jane B. Lian, Janet L. Stein, Gary S. Stein, André J. van Wijnen, Fernando Cruzat
      Pages 189-209
    7. Adriana S. Dusso, Masanori Tokumoto
      Pages 211-234
    8. Justin Silver, Tally Naveh-Many
      Pages 235-254
    9. Carsten Carlberg
      Pages 255-274
  3. Non-skeletal/Functions of Vitamin D

    1. Front Matter
      Pages 275-275
    2. Philip T. Liu, Martin Hewison, John S. Adams
      Pages 297-310
    3. Heide S. Cross, Meinrad Peterlik
      Pages 311-323
    4. María Jesús Larriba, Alberto Muñoz
      Pages 325-334
    5. Louise Harvey, Thomas Burne, Xiaoying Cui, Alan Mackay-Sim, Darryl Eyles, John McGrath
      Pages 335-344
    6. Michael B. Zemel, Xiaocun Sun
      Pages 345-358
  4. Vitamin D Status – Global Analysis

    1. Front Matter
      Pages 359-359
    2. Mona S. Calvo, Susan J. Whiting
      Pages 361-382
    3. N. Binkley, G. Lensmeyer
      Pages 383-399
    4. Douglass Bibuld
      Pages 401-424
    5. David A. Hanley
      Pages 425-433
    6. Jose Manuel Quesada Gomez, Manuel Diaz Curiel
      Pages 453-467
    7. Ann Prentice, Inez Schoenmakers, Kerry S. Jones, Landing M.A. Jarjou, Gail R. Goldberg
      Pages 505-528
    8. R.K. Marwaha, R. Goswami
      Pages 529-542
    9. C. V. Harinarayan, Shashank R. Joshi
      Pages 543-561
    10. Tim Green, Bernard Venn
      Pages 563-587
    11. Mark J. Bolland, Ian R. Reid
      Pages 589-601
    12. Reinhold Vieth
      Pages 603-612
  5. Health Consequences of Vitamin D Deficiency and Resistance on Musculoskeletal Health

    1. Front Matter
      Pages 613-613
    2. Sarah N. Taylor, Carol L. Wagner, Bruce W. Hollis
      Pages 615-631
    3. Amy D. DiVasta, Kristen K. van der Veen, Catherine M. Gordon
      Pages 633-650
    4. John M. Pettifor, Philip R. Fischer, Tom D. Thacher
      Pages 651-667
    5. Marie B. Demay
      Pages 679-689
    6. John S. Adams, Hong Chen, Thomas S. Lisse, Rene F. Chun, Martin Hewison
      Pages 715-728
  6. Sunlight, Vitamin D and Cancer

    1. Front Matter
      Pages 743-743
    2. Johan Moan, Øyvind Sverre Bruland, Arne Dahlback, Asta Juzeniene, Alina Carmen Porojnicu
      Pages 765-775
    3. Edward Giovannucci
      Pages 777-795
    4. Edward D. Gorham, Sharif B. Mohr, Frank C. Garland, Cedric F. Garland
      Pages 813-840

About this book


In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus.

The first edition of Vitamin D: Physiology, Molecular Biology and Clinical Applications was the benchmark in the field when published in 1999. This new and expanded volume continues to include extensive, in-depth chapters covering the most important aspects of the complex interactions between vitamin D and other dietary components, the ongoing debate concerning the best indicator of optimal vitamin D status and its nutrient requirements, and the impact of less than optimal status on disease risk. Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.


Absorption Calcium Fluor Metabolite Nutrition Vitamin D bone health cancer prevention

Editors and affiliations

  • Michael F. Holick
    • 1
  1. 1.BostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-60327-300-8
  • Online ISBN 978-1-60327-303-9
  • Buy this book on publisher's site