mTOR Pathway and mTOR Inhibitors in Cancer Therapy

  • Vitaly A. Polunovsky
  • Peter J. Houghton

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Henry Mead, Mirjana Zeremski, Markus Guba
    Pages 49-74
  3. James Brugarolas
    Pages 75-97
  4. David Akhavan, Paul S. Mischel
    Pages 99-111
  5. Peter J. Houghton
    Pages 113-131
  6. Sandrine Faivre, Thomas Decaens, Eric Raymond
    Pages 133-148
  7. Bruno D. Fonseca, Christopher G. Proud
    Pages 179-200
  8. Ryan J. O. Dowling, Nahum Sonenberg
    Pages 201-216
  9. Ola Larsson, Peter B. Bitterman
    Pages 217-236
  10. Peter B. Bitterman, Vitaly A. Polunovsky
    Pages 237-255
  11. Back Matter
    Pages 287-301

About this book


mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment – targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. In this work, experts in TOR signaling have contributed in two thematic areas: mTOR Signaling and Cancer Therapy (chapters 1 - 8) and Therapeutic Targeting Downstream of mTOR (chapter 9 – 13). All chapters of mTOR Pathway and mTOR Inhibitors in Cancer Therapy are completely new or have been extensively updated by their authors; and we are indebted to all authors who have exemplified the links between these 2 thematic areas.


Cancer Therapy angiogenesis genes mTOR Inhibitors mTOR Pathway regulation saccharomyces cerevisiae translation

Editors and affiliations

  • Vitaly A. Polunovsky
    • 1
  • Peter J. Houghton
    • 2
  1. 1.Dept. Family MedicineUniversity of MinnesotaMinneapolisUSA
  2. 2.Director, Center for Childhood Cancer, Nationwide Children’s HospitalThe Research InstituteColumbusUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Medicine
  • Print ISBN 978-1-60327-270-4
  • Online ISBN 978-1-60327-271-1
  • Buy this book on publisher's site