Chemokine Receptors in Cancer

  • Amy M.¬†Fulton
Book

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-x
  2. Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland, Shaun R McColl
    Pages 1-30
  3. Bungo Furusato, Johng S. Rhim
    Pages 31-45
  4. Elizabeth W. Newcomb, David Zagzag
    Pages 47-61
  5. Yanchun Li, Amy M. Fulton
    Pages 79-91
  6. Lei Fang, Sam T. Hwang
    Pages 93-108
  7. Gali Soria, Adit Ben-Baruch
    Pages 109-130
  8. B. Mehrad, R. M. Strieter
    Pages 131-151
  9. Thorsten Eismann, Nadine Huber, Alex B. Lentsch
    Pages 153-170
  10. Back Matter
    Pages 171-176

About this book

Introduction

Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

Keywords

angiogenesis cytokines metastasis prostate cancer tumor

Editors and affiliations

  • Amy M.¬†Fulton

There are no affiliations available

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60327-267-4
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60327-266-7
  • Online ISBN 978-1-60327-267-4
  • About this book