Regulatory Networks in Stem Cells

  • Vinagolu K. Rajasekhar
  • Mohan C. Vemuri

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Molecular Regulation in Stem Cells

    1. Front Matter
      Pages 1-1
    2. Bridget M. Deasy
      Pages 13-26
    3. Atsushi Suzuki, Ángel Raya, Yasuhiko Kawakami, Masanobu Morita, Takaaki Matsui, Kinichi Nakashima et al.
      Pages 37-53
    4. Nina J. Kossack, Joerg Gromoll, Renee A. Reijo Pera
      Pages 55-66
    5. Irene Riz, Robert G. Hawley
      Pages 67-74
    6. Dimitris G. Placantonakis, Mark J. Tomishima, Fabien G. Lafaille, Lorenz Studer
      Pages 75-86
    7. Emily Walker, William L. Stanford
      Pages 87-100
    8. Colleen E. Albacker, Leonard I. Zon
      Pages 101-110
    9. Mohan C. Vemuri
      Pages 111-122
    10. Eiso Hiyama, Keiko Hiyama
      Pages 123-134
    11. Claudia Nesti, Livia Pasquali, Michelangelo Mancuso, Gabriele Siciliano
      Pages 137-143
  3. Regulation by Stem Cell Niches

    1. Front Matter
      Pages 145-145
    2. Hiroko Iwasaki, Toshio Suda
      Pages 165-173
    3. Thomas P. Lozito, Catherine M. Kolf, Rocky S. Tuan
      Pages 185-210
    4. Suzanne M. Watt, Grigorios Tsaknakis, Sinead P. Forde, Lee Carpenter
      Pages 211-231
  4. Epigenetic Mechanisms in Stem Cells

    1. Front Matter
      Pages 233-233
    2. Joyce E. Ohm, Stephen B. Baylin
      Pages 235-246
    3. Monther Abu-Remaileh, Yehudit Bergman
      Pages 247-256
    4. Philippe Collas, Sanna Timoskainen, Agate Noer
      Pages 257-268
    5. Bhaskar Thyagarajan, Mahendra Rao
      Pages 269-276
    6. Laurie Jackson-Grusby
      Pages 277-284
  5. Signaling and Regulation in Select Stem Cell Types

    1. Front Matter
      Pages 291-291
    2. D. Reynolds, Ludovic Vallier, Zhenzhi Chng, Roger Pedersen
      Pages 293-308
    3. Tohru Kimura, Toru Nakano
      Pages 309-318
    4. Daylon James, Marco Seandel, Shahin Rafii
      Pages 319-328
    5. Vivek M. Tanavde, Lailing Liew, Jiahao Lim, Felicia Ng
      Pages 329-335
    6. Weijia Wang, Julie Audet
      Pages 337-345
    7. Malcolm A.S. Moore
      Pages 347-377
    8. Takashi Yokoo, Akira Fukui, Kei Matsumoto, Tetsuya Kawamura
      Pages 379-390
    9. Caroline E. Gargett, Kjiana E. Schwab
      Pages 391-404
    10. Chew-Li Soh, Joanna M.C. Lim, Richard L. Boyd, Ann P. Chidgey
      Pages 405-437
    11. Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Naoya Kobayashi
      Pages 439-469
  6. Disease Paradigms and Stem Cell Therapeutics

    1. Front Matter
      Pages 471-471
    2. Bikul Das, Rika Tsuchida, Sylvain Baruchel, David Malkin, Herman Yeger
      Pages 473-487
    3. Stewart Sell
      Pages 495-503
    4. Xiao-Feng Yang, Hong Wang
      Pages 505-518
    5. Dominique Bonnet
      Pages 519-526
    6. Tobias Schatton, Natasha Y. Frank, Markus H. Frank
      Pages 527-543
    7. Lisa R. Rogers, Maxs Wicha
      Pages 545-560
    8. Matthew T. Harting, Charles S. Cox, Stephen G. Hall
      Pages 561-573
    9. Mathew Blurton-Jones, Tritia R. Yamasaki, Frank M. LaFerla
      Pages 575-583
  7. Back Matter
    Pages 585-601

About this book


This book ambitiously incorporates all the latest and essential subjects on molecular regulation in embryonic, tissue, and cancer stem cells. The chapter on pathology and therapy is also fairly informative.

I highly appreciate rigorous effort by all the editors and contributors, and strongly recommend this book to experts as well as students

- Dr. Shinya Yamanaka, Kyoto University, Japan


This new volume provides a broad overview of the regulation of stem cell renewal and differentiation from a diverse panel of expert authors.  The chapters cover a remarkable range of topics, from molecular biology and model systems to translational and clinical implications of stem cell research.  The book will be useful to both students and experienced researchers in the field.

- Dr. Martin Pera, University of Southern California, Los Angeles, CA. USA.


The application of stem cell 'thinking' and stem cell science to the biology of development, to tissue homeostasis, and to the generation of cancers has resulted in the explosion of new experiments and new models over the past several years. The rate of knowledge accumulation exceeds the abilities of most scientists, and especially aging scientists, to digest by reading the primary literature. Here Rajasekhar and Vemuri have brought together essays and reviews by world leaders in all areas of stem cell research--tissue and organ [adult] stem and progenitor cells, cancer stem cells, classical embryonic pluripotent stem cells, and pluripotent stem cells derived by nuclear reprogramming of adult somatic mature cell nuclei. It even covers the fast breaking field of induced pluripotent stem [iPS] cells, somatic cells that were reprogrammed by the transfection of as little as 3 genes whose gene products can re-set the genome of a mature cell to that of a pluripotent cell.  The potentials of all of these areas to study and begin to understand human developmental biology, to produce from patients with genetic diseases pluripotent stem cells that can make all of the cell types affected in the disease, and the obvious translational attempts with tissue and organ stem cells promises to make these approaches, and the reviews in this book, the center of research in regenerative medicine. The identification of cancer stem cell in those cancers that have them [not cancers of stem cells, but the intratumoral cell subset that regenerates the entire tumor while self-renewing] will certainly help provide targets for drug therapies and novel imaging agents in the identified signal transduction pathways they use; and immunotherapy targets by the novel proteins and peptides [at least]that are created by mutations, translocations, and splicing anomalies central to the oncogenic progression in these cancer stem cells. The book is an essential addition to the libraries of scientists and institutions that do and teach stem cell research. I commend the editors and authors for an excellent and exciting book.

- Irv Weissman MD, Stanford University


DNA Expression Telomere anatomy cells developmental biology endothelium gene expression genes genetics miRNAs molecular biology ontogeny surgery transcription

Editors and affiliations

  • Vinagolu K. Rajasekhar
    • 1
  • Mohan C. Vemuri
    • 2
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Invitrogen CorporationFrederickUSA

Bibliographic information