Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

  • Benjamin Bonavida

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Sensitization via Membrane-Bound Receptors

    1. H. Peter Vollmers, Stephanie Brändlein
      Pages 3-11
    2. Tracy R. Daniels, Isabel I. Neacato, Gustavo Helguera, Manuel L. Penichet
      Pages 13-27
    3. Benjamin Bonavida, Ali R. Jazirehi, Mario I. Vega, Sara Huerta-Yepez, Kazuo Umezawa, Eriko Suzuki
      Pages 29-39
    4. Tatsushi Yoshida, Toshiyuki Sakai
      Pages 41-49
    5. Milad Motarjemi, William H. D. Hallett, Minghui Li, William J. Murphy
      Pages 51-60
  3. Sensitization via Inhibition of Cell Survival Pathways (Excluding Apoptotic Signaling Pathways)

    1. James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, William H. Chappell, Melissa L. Midgett et al.
      Pages 81-114
    2. Roberto R. Rosato, Steven Grant
      Pages 115-131
  4. Sensitization via Transcription Factors

    1. Devasis Chatterjee, Edmond Sabo, Murray B. Resnick, Kam C. Yeung, Y. Eugene Chin
      Pages 159-174
    2. Flavio Maina, Rosanna Dono
      Pages 189-202
    3. Benjamin Bonavida, Sara Huerta-Yepez, Mario I. Vega, Demetrios A. Spandidos, Stravoula Baritaki
      Pages 203-210
    4. Ganesh Jagetia, Sunil Krishnan Krishnan, Bharat B. Aggarwal
      Pages 211-240
  5. Sensitization via Targeting Apoptotic Pathways

    1. Timothy R. Wilson, Daniel B. Longley, Patrick G. Johnston
      Pages 263-278
    2. Shantanu Banerji, Sudharsana Rao Ande, Subbareddy Maddika, Versha Banerji, Iran Rashedi, Neil W. Owens et al.
      Pages 279-303
    3. Ruud P. M. Dings, Mark Klein, Kevin H. Mayo
      Pages 305-325
  6. Sensitization Tailored to Individual Patients

    1. Thomas Efferth, Michael Wink
      Pages 365-387
    2. Erika Cecchin, Massimo Libra, Calogero Cannavò, Bibiana Bruni, Alberto Fulvi, Giuseppe Toffoli et al.
      Pages 389-403
  7. Back Matter
    Pages 405-419

About this book


Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.


Sensitization angiogenesis apoptosis apoptotic chemotherapeutic agents inhibitors membrane-bound receptors metastatic disease pathways positron emission tomography siRNA transcription factors

Editors and affiliations

  • Benjamin Bonavida
    • 1
  1. 1.University of California at Los AngelesLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-934115-29-9
  • Online ISBN 978-1-59745-474-2
  • Buy this book on publisher's site