Principles of Molecular Oncology

  • Miguel H. Bronchud
  • Mary Ann Foote
  • Giuseppe Giaccone
  • Olufunmilayo Olopade
  • Paul Workman

Table of contents

  1. Front Matter
    Pages i-xix
  2. Miguel H. Bronchud
    Pages 1-26
  3. N. Lynn Henry, Daniel F. Hayes
    Pages 27-41
  4. Elena Tamborini, Federica Perrone, Milo Frattini, Tiziana Negri, Antonella Aiello, Annunziata Gloghini et al.
    Pages 43-84
  5. Tatyana A. Grushko, Olufunmilayo I. Olopade
    Pages 85-105
  6. Alan Horwich, Gill Ross
    Pages 107-116
  7. Xiang Sean Yu, Raymond K. Blanchard, Yexun Wang, Min You
    Pages 135-152
  8. Daniel Kalderon
    Pages 153-188
  9. Jing Peng, V. Craig Jordan
    Pages 189-206
  10. Jaume Piulats, Francesc Mitjans
    Pages 239-256
  11. Frank A.E. Kruyt, Jose A. Rodriguez, Giuseppe Giaccone
    Pages 257-268
  12. Gabriel Capellá, Josep Balart, Miguel Angel Peinado
    Pages 269-279
  13. Isabel López de Silanes, Manel Esteller
    Pages 281-291
  14. Teresa Macarulla, Francisco Javier Ramos, Josep Tabernero
    Pages 307-315
  15. Alison H.M. Reid, Richard Baird, Paul Workman
    Pages 317-365
  16. Silke Schepelmann, Ion Niculescu-Duvaz, Caroline J. Springer
    Pages 367-382
  17. Rosario García-Campelo, Miquel Tarón, Itziar De Aguirre, Pedro Méndez, Rafael Rosell
    Pages 383-390

About this book

Introduction

Drawing on years of significant scientific advances and clinical developments, the editors of POMO III have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition (2004) reaffirmed this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins- with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, POMO III not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce the process of carcinogenesis, cancer cell proliferation and significantly reduce metastasis.

Keywords

DNA Microarray Proteomics diagnostics gene expression genes genotypes signal transduction

Editors and affiliations

  • Miguel H. Bronchud
    • 1
  • Mary Ann Foote
    • 2
  • Giuseppe Giaccone
    • 3
  • Olufunmilayo Olopade
    • 4
  • Paul Workman
    • 5
  1. 1.Hospital General of GranollersBarcelonaSpain
  2. 2.MA Foote AssociatesWestlake VillageUSA
  3. 3.National Cancer InstituteBethesdaMaryland
  4. 4.University of Chicago Medical CenterChicagoUSA
  5. 5.CRC Center for Cancer TherapeuticsSurreyUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-470-4
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-934115-25-1
  • Online ISBN 978-1-59745-470-4
  • About this book