Table of contents

  1. Front Matter
    Pages i-xi
  2. Jean-Jacques Brière, Paule Bénit, Pierre Rustin
    Pages 19-32
  3. Pauline M. Carrico, Nadine Hempel, J. Andrés Melendez
    Pages 33-44
  4. Roberto Scatena, Patrizia Bottoni, Bruno Giardina
    Pages 45-54
  5. Sarika Srivastava, Carlos T. Moraes
    Pages 55-72
  6. Túlio César Ferreira, Élida Geralda Campos
    Pages 73-90
  7. Shireesh P. Apte, Rangaprasad Sarangarajan
    Pages 103-118
  8. Anna Czarnecka, Ewa Bartnik
    Pages 119-130
  9. Luis F. Gonzalez-Cuyar, Fabio Tavora, Iusta Caminha, George Perry, Mark A. Smith, Rudy J. Castellani
    Pages 131-144
  10. M. Karen Newell, Elizabeth M. Villalobos-Menuey, Marilyn Burnett, Robert E. Camley
    Pages 145-160
  11. Erica Werner
    Pages 161-178
  12. Back Matter
    Pages 179-195

About this book

Introduction

Cellular Respiration and Carcinogenesis informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text by leading experts in the field, offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanisms or pathways of cellular respiration; oxidative phosphorylation and glycolysis.  The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse of cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.

 

 

About the Editors:

Shireesh P.Apte, Ph.D has 10+ years experience in the pharmaceutical industry researching and formulating anti-cancer drugs. He holds one US patent and has 10+ related publications. He is a member of the US Pharmacopoeia excipients expert committee.

Rangaprasad Sarangarajan, Ph.D. has over 10 years of research experience in an academic setting with extensive publications in areas of pharmacology & toxicology with focus on cancer treatment.  He is active member of various professional organizations including the Society of Toxicology, American Society for Pharmacology & Toxicology and Pan American Society for Pigment Cell Research.

Keywords

DNA cancer carcinogenesis cell cell death development genes metabolism mitochondria mutation programmed cell death regulation tumor tumors

Editors and affiliations

  • Rangaprasad Sarangarajan
  • Shireesh Apte
  1. 1.Health Sciences (MCPHS)Massachusetts College of Pharmacy &WorcesterU.S.A.
  2. 2.Alcon Research Ltd.Forth WorthU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-435-3
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-934115-07-7
  • Online ISBN 978-1-59745-435-3
  • About this book