Leukemia

Methods and Protocols

  • Chi Wai Eric So

Part of the Methods in Molecular Biology™ book series (MIMB, volume 538)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Joseph Wiemels, Michelle Kang, Mel Greaves
    Pages 7-27
  3. Bernd B. Zeisig, Chi Wai Eric So
    Pages 207-229
  4. Andrei V. Krivtsov, Yingzi Wang, Zhaohui Feng, Scott A. Armstrong
    Pages 231-246
  5. Dominique Bonnet
    Pages 247-262
  6. Patrycja Sroczynska, Christophe Lancrin, Stella Pearson, Valerie Kouskoff, Georges Lacaud
    Pages 317-334
  7. Katrin Ottersbach, Elaine Dzierzak
    Pages 335-346
  8. Maria-Paz Garcia-Cuellar, Deniz Mederer, Robert K. Slany
    Pages 347-367
  9. Glenda J. Dickson, Terence R. Lappin, Alexander Thompson
    Pages 369-393

About this book

Introduction

Recent advances in molecular and cellular biology techniques have significantly improved our ability to detect, monitor, model and study the underlying molecular basis and pathogenesis of leukemia, yet we are still in an early discovery stage and much more work is needed in order to develop better strategies to diagnose, classify and treat this biologically and clinically diverse disease. In Leukemia: Methods and Protocols, expert researchers bring together a wide range of state-of-the-art laboratory methods and detailed protocols that are useful for both clinical and basic research scientists working on the disease. The volume provides techniques for prenatal backtracking of leukemic clone, molecular diagnosis, detection of genome-wide genetic abnormalities and profiling, identification of unknown fusion genes, monitoring of minimal residual diseases, disease modeling using murine and human primary hematopoietic cells, studying of normal and malignant hematopoiesis, identification of interacting partners with leukemia associated oncoproteins, and global characterization of genome-wide epigenetic changes in leukemic cells. Written in the highly successful Methods in Molecular Biology™ series format, the convenient chapters contain brief introductions, lists of the necessary materials, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Comprehensive and cutting-edge, Leukemia: Methods and Protocols will help researchers to advance knowledge and have a better understanding of the disease, which will ultimately facilitate development of anti-cancer therapy and improve quality of life for patients.

Keywords

Anti-cancer therapy Disease modeling Experimental hematology Hematological malignancies Laboratory Molecular diagnosis

Editors and affiliations

  • Chi Wai Eric So

There are no affiliations available

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-418-6
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-989-5
  • Online ISBN 978-1-59745-418-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book