© 2010

Molecular Basis of Pulmonary Disease

Insights from Rare Lung Disorders

  • Francis X. McCormack
  • Ralph J. Panos
  • Bruce C. Trapnell

Part of the Respiratory Medicine book series (RM)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ralph J. Panos
    Pages 1-30
  3. Jeffrey Krischer
    Pages 31-38
  4. Jean M. Elwing, Gail H. Deutsch, William C. Nichols, Timothy D. Le Cras
    Pages 39-84
  5. Elizabeth P. Henske, Francis X. McCormack
    Pages 85-110
  6. Bruce C. Trapnell, Koh Nakata, Yoshikazu Inoue
    Pages 111-131
  7. Ralph J. Panos, James P. Bridges
    Pages 133-166
  8. Claire Shovlin, S. Paul Oh
    Pages 167-188
  9. Lisa R. Young, William A. Gahl
    Pages 189-207
  10. Charlie Strange, Sabina Janciauskiene
    Pages 209-224
  11. Amaresh Nath, Enid R. Neptune
    Pages 225-245
  12. Lawrence M. Nogee
    Pages 247-265
  13. Edward D. Chan, Kathryn Chmura, Andrew Sullivan
    Pages 267-273
  14. Gangadhar Taduri, Raghu Kalluri, Ralph J. Panos
    Pages 275-292
  15. Michael R. Knowles, Hilda Metjian, Margaret W. Leigh, Maimoona A. Zariwala
    Pages 293-323
  16. Koichi Hagiwara, Takeshi Johkoh, Teruo Tachibana
    Pages 325-338
  17. André M. Cantin
    Pages 339-368
  18. Ralph J. Panos, Andrew P. Fontenot
    Pages 389-408
  19. Brent W. Kinder
    Pages 409-419

About this book


The study of rare lung disorders enhances our understanding of common pulmonary diseases such as fibrosis and emphysema. Molecular Basis of Pulmonary Disease: Insights from Rare Lung Disorders brings together a panel of distinguished clinicians and molecular scientists who are experts in a range of rare lung diseases and their underlying molecular defects. Each chapter focuses on the pathogenic mechanisms and therapeutic targets suggested by basic research and follows an easy-to-read format: brief introduction followed by discussion of epidemiology, genetic basis and molecular pathogenesis, animal models, clinical presentation, diagnostic approaches, conventional management and treatment strategies, as well as future therapeutic targets and directions. Disorders ranging from the Marfan and Goodpasture’s syndromes to Sarcoidosis and alpha one antitrypsin deficiency are treated in detail. Written for pulmonary clinicians and scientists alike, Molecular Basis of Pulmonary Disease: Insights from Rare Lung Disorders is a comprehensive and invaluable nesource that sheds new light on the molecular mechanisms influencing the clinical presentation and treatment strategies for these debilitating disorders.


Atmen Basis Disease Disorders Insights Lung Medicine Molecular Pulmonary Rare Respiratory

Editors and affiliations

  • Francis X. McCormack
    • 1
  • Ralph J. Panos
    • 2
  • Bruce C. Trapnell
    • 3
  1. 1.Div. Pulmonary & Critical CareUniversity of CincinnatiCincinnatiUSA
  2. 2.Div. Pulmonary & Critical CareUniversity of CincinnatiCincinnatiUSA
  3. 3.Medical CenterCincinnati Children's HospitalCincinnatiUSA

Bibliographic information

  • Book Title Molecular Basis of Pulmonary Disease
  • Book Subtitle Insights from Rare Lung Disorders
  • Editors Francis X. McCormack
    Ralph J. Panos
    Bruce C. Trapnell
  • Series Title Respiratory Medicine
  • Series Abbreviated Title Respiratory Medicine
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-963-5
  • Softcover ISBN 978-1-4939-6081-1
  • eBook ISBN 978-1-59745-384-4
  • Edition Number 1
  • Number of Pages XI, 438
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pneumology/Respiratory System
  • Buy this book on publisher's site


From the reviews:

“This unique book attempts to briefly review the clinical manifestations and evolution of a few uncommon, mostly very rare pulmonary disorders, some of which even subspecialist pulmonologists rarely or never encounter during their careers. … The editors derive insight and input from contributors of eclectic knowledge and experience. … Certainly, the audience would be limited to basic scientists and a modicum of clinicians with unique interests. … The book achieves its likely intended goals well. … a potentially useful addition to my medical library.” (Joel C. Seidman, Doody’s Review Service, July, 2010)