Advertisement

G-Quadruplex DNA

Methods and Protocols

  • Peter Baumann

Part of the Methods in Molecular Biology book series (MIMB, volume 608)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Tracy M. Bryan, Peter Baumann
    Pages 1-16
  3. Nichola C. Garbett, Chongkham S. Mekmaysy, Jonathan B. Chaires
    Pages 97-120
  4. Robert D. Gray, Luigi Petraccone, Robert Buscaglia, Jonathan B. Chaires
    Pages 121-136
  5. Timur I. Gaynutdinov, Ronald D. Neumann, Igor G. Panyutin
    Pages 137-145
  6. Christiane Schaffitzel, Jan Postberg, Katrin Paeschke, Hans J. Lipps
    Pages 159-181
  7. Jasmine S. Smith, F. Brad Johnson
    Pages 207-221
  8. Roxanne Kieltyka, Pablo Englebienne, Nicolas Moitessier, Hanadi Sleiman
    Pages 223-255
  9. Back Matter
    Pages 273-276

About this book

Introduction

Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In G-Quadruplex DNA: Methods and Protocols, experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, G-Quadruplex DNA: Methods and Protocols promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.

Keywords

DNA Drug development G-quartet formation and dynamics Guanine bases Molecular recognition Oligonucleotides Telomerase activity microscopy molecular biology transcription

Editors and affiliations

  • Peter Baumann
    • 1
  1. 1.Medical ResearchStowers Institute forKansas CityU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-363-9
  • Copyright Information Humana Press 2010
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-950-5
  • Online ISBN 978-1-59745-363-9
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site