Acute Myelogenous Leukemia

  • Judith E. Karp

Part of the Contemporary Hematology book series (CH)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Overview of AML

    1. Front Matter
      Pages 1-1
    2. Farhad Ravandi, Francis Giles
      Pages 3-23
  3. Molecular Foundations of AML Pathogenesis and Physiology

    1. Front Matter
      Pages 25-25
    2. Alan D. Friedman
      Pages 27-42
    3. Jane E. Parker
      Pages 43-70
    4. Lucy A. Godley, Michelle M. Le Beau
      Pages 71-95
    5. David P. Steensma
      Pages 97-131
    6. Ruben A. Mesa, Scott H. Kaufmann
      Pages 133-161
    7. Douglas D. Ross
      Pages 163-173
  4. Translating Biology into Clinical Application

    1. Front Matter
      Pages 175-175
    2. Olga Frankfurt, LoAnn C. Peterson, Robert Gallagher, Martin S. Tallman
      Pages 193-228
  5. Molecular Therapeutics of AML: Selected Targeted Approaches

    1. Front Matter
      Pages 229-229
    2. Edward A. Sausville
      Pages 231-246
    3. Tamer Fandy, Hetty Carraway, Steven D. Gore
      Pages 275-291
    4. Tara L. Lin, William Matsui
      Pages 293-312
    5. Javier Bolaños-Meade, Richard J. Jones
      Pages 313-327
    6. Ivan Borrello
      Pages 329-341
  6. Special Challenges

  7. Back Matter
    Pages 417-426

About this book


Acute Myelogenous Leukemia is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas, and both basic and clinical scientists will benefit from this translational text.


DNA apoptosis cell clinical trial cytogenetics genetics leukemia pathogenesis pathophysiology physiology stem cell stem cell transplantation transplantation tumor

Editors and affiliations

  • Judith E. Karp
    • 1
  1. 1.The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2007
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-621-4
  • Online ISBN 978-1-59745-322-6
  • Buy this book on publisher's site