Stem Cells And Myocardial Regeneration

  • Marc S. Penn

Part of the Contemporary Cardiology book series (CONCARD)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Economic impact of heart failure

    1. Marc S. Penn, Eric J. Topol
      Pages 1-6
  3. Cells Of Interest For Myocardial Regeneration

    1. Front Matter
      Pages 7-7
    2. Donald Orlic, Richard O. Cannon III
      Pages 9-28
    3. Mark F. Pittenger
      Pages 29-44
    4. Wouter van’t Hof, Niladri Mal, Amy Raber, Ming Zhang, Anthony Ting, Marc S. et al.
      Pages 45-56
    5. Elisa Messina, Alessandro Giacomello, Eduardo Marbán
      Pages 83-100
    6. Lior Gepstein
      Pages 101-114
  4. Mechanisms And Critical Pathways Involved In Myocardial Repair

    1. Front Matter
      Pages 115-115
    2. William R. Mills, Kenneth R. Laurita
      Pages 159-170
  5. Strategies For Cell Delivery: Advantages/Disadvantages

    1. Front Matter
      Pages 171-171
    2. Matthew Hook, Patrick Whitlow
      Pages 173-180
    3. Roberto Lorusso, Josè L. Navia, Cesare Beghi, Fernando A. Atik
      Pages 181-202
  6. Stem Cell-Based Clinical Trials For Cardiac Dysfunction

    1. Front Matter
      Pages 203-203
    2. Jaber Wael A., Cerqueira Manuel D.
      Pages 205-220
    3. Chronic Heart Failure

      1. Emerson C. Perin, Guilherme V. Silva
        Pages 223-244
      2. Amit N. Patel, Jorge Genovese
        Pages 245-258
      3. Anthony W. Ashton, David D’Alessandro, Robert E. Michler
        Pages 259-274
    4. Acute Myocardial Infarction

      1. Marc S. Penn, Samuel Unzek, Niladri Mal, Kai Wang
        Pages 277-284
  7. Summary/Future Challenges

    1. Front Matter
      Pages 295-295
    2. Marc S. Penn
      Pages 297-302
  8. Back Matter
    Pages 303-316

About this book


Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.


angiogenesis cardiovascular cell cell differentiation cytokine heart hematopoietic stem cell regeneration stem cell stem cells transplantation vascular disease

Editors and affiliations

  • Marc S. Penn
    • 1
  1. 1.Bakken Heart Brain Institute and Coronary Intensive Care UnitThe Cleveland Clinic Foundation Cleveland

Bibliographic information

  • DOI
  • Copyright Information Humana Press Inc. 2007
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-664-1
  • Online ISBN 978-1-59745-272-4
  • Buy this book on publisher's site