Apoptosis, Senescence, and Cancer

  • David A. Gewirtz
  • Shawn E. Holt
  • Steven Grant

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Apoptosis and Alternative Modes of Cell Death

    1. Front Matter
      Pages 1-1
    2. Scott H. Kaufmann
      Pages 3-30
    3. M. Stacey Ricci, Wafik S. El-Deiry
      Pages 31-54
    4. Fiorenza Ianzini, Michael A. Mackey
      Pages 73-91
    5. Mojgan Djavaheri-Mergny, Joëlle Botti, Patrice Codogno
      Pages 93-107
  3. Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis

    1. Front Matter
      Pages 123-123
    2. Jay E. Johnson, Dominique Broccoli
      Pages 125-144
    3. Ruben D. Ramirez
      Pages 145-157
    4. Richard Possemato, William C. Hahn
      Pages 159-171
    5. John P. Murnane
      Pages 173-189
  4. DNA Damage Response, Signaling Pathways, and Tumorigenesis

    1. Front Matter
      Pages 191-191
    2. Aude Duprè, Jean Gautier
      Pages 193-221
    3. Kirsteen H. Maclean, John L. Cleveland
      Pages 223-241
  5. Resistance and Sensitization

    1. Front Matter
      Pages 279-279
    2. Paul Dent, David T. Curiel, Paul B. Fisher
      Pages 281-298
    3. Myles C. Cabot
      Pages 299-312
    4. Debra L. Smith, Laura K. Nolden, Gordon B. Mills, Yiling Lu
      Pages 313-334
  6. Established Cancer Therapies

    1. Front Matter
      Pages 359-359
    2. Janet A. Houghton
      Pages 361-382
    3. Olivier Sordet, Yves Pommier, Eric Solary
      Pages 383-406
    4. Annette K. Larsen, DVM PhD, Andrzej Skladanowski, PhD DSc
      Pages 407-422
    5. Michael Deininger
      Pages 477-508
  7. Recent and Developing Cancer Therapies

    1. Front Matter
      Pages 509-509
    2. Richard R. Furman, John P. Leonard, Julian Decter, Morton Coleman
      Pages 511-536
    3. Jennifer A. Doll PhD, Jennifer E. Hobbs PhD, Gerald A. Soff MD
      Pages 537-555
    4. Nancy L. Oleinick, Rachel L. Morris, Anna-Liisa Nieminen
      Pages 557-578
    5. Simone Fulda, Klaus-Michael Debatin
      Pages 579-591
  8. Back Matter
    Pages 593-599

About this book


Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.

The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies.

In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.


Tumor apoptosis lead senescence tumorigenesis

Editors and affiliations

  • David A. Gewirtz
    • 1
  • Shawn E. Holt
    • 2
  • Steven Grant
    • 3
  1. 1.Department of Pharmacology and Toxicology and Massey Cancer CenterVirginia Commonwealth UniversityVA
  2. 2.Departments of Medicine, Pharmacology and ToxicologyBiochemistry and Massey Cancer CenterVirginia CommonwealthVA
  3. 3.Departments of Pathology, Human Genetics, Pharmacology and ToxicologyBiochemistry and Massey Cancer CenterVirginia CommonwealthVA

Bibliographic information