Prenatal Diagnosis

  • Sinuhe Hahn
  • Laird G. Jackson

Part of the Methods in Molecular Biology™ book series (MIMB, volume 444)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Invasive Approaches

    1. Front Matter
      Pages 1-1
    2. Susanne Mergenthaler-Gatfield, Wolfgang Holzgreve, Sinuhe Hahn
      Pages 3-26
    3. Catherine D. Kashork, Aaron Theisen, Lisa G. Shaffer
      Pages 59-70
    4. Kathy Mann, Erwin Petek, Barbara Pertl
      Pages 71-94
    5. Bernhard G. Zimmermann, Lech Dudarewicz
      Pages 95-109
    6. Jan Schouten, Robert-Jan Galjaard
      Pages 111-122
    7. Dorothy J. Huang, Matthew R. Nelson, Wolfgang Holzgreve
      Pages 123-132
    8. Joanne Traeger-Synodinos, Christina Vrettou, Emmanuel Kanavakis
      Pages 133-145
    9. Esther Guetta, Leah Peleg
      Pages 147-159
    10. Barbara Foglieni, Silvia Galbiati, Maurizio Ferrari, Laura Cremonesi
      Pages 169-182
  3. Noninvasive Approaches

    1. Front Matter
      Pages 184-184
    2. Dorothy J. Huang, Susanne Mergenthaler-Gatfield, Sinuhe Hahn, Wolfgang Holzgreve, Xiao Yan Zhong
      Pages 203-208
    3. Tobias J. Legler, Klaus-Hinrich Heermann, Zhong Liu, Aicha Ait Soussan, C. Ellen van der Schoot
      Pages 209-218
    4. Bernhard G. Zimmermann, Deborah G. Maddocks, Neil D. Avent
      Pages 219-229
    5. Yuditiya Purwosunu, Akihiko Sekizawa, Takashi Okai
      Pages 231-238
    6. Xiao Yan Zhong, Wolfgang Holzgreve, Dorothy J. Huang
      Pages 269-273
    7. Attie T. J. J. Go, Allerdien Visser, Marie van Dijk, Monique A. M. Mulders, Paul Eijk, Bauke Ylstra et al.
      Pages 291-302
    8. Olav Lapaire, Kirby L. Johnson, Diana W. Bianchi
      Pages 303-309
    9. Chinnapapagari Satheesh Kumar Reddy, Wolfgang Holzgreve, Sinuhe Hahn
      Pages 311-326
  4. Back Matter
    Pages 327-331

About this book


With molecular biology now allowing greater accuracy in prenatal diagnosis given amounts of fetal material as small as single cells, a major current focus has grown in the development of rapid, cost-effective diagnoses.  In Prenatal Diagnosis, top experts provide cutting edge applications for the rapid assessment of fetal aneuploidies and Mendelian disorders on fetal material gained by invasive approaches, as well as procedures being validated for routine, non-invasive clinical analysis of cell free fetal DNA.  Following the Methods in Molecular Biology™ series format, the chapters feature step-by-step laboratory protocols, lists of the necessary materials, and tips on troubleshooting and avoiding known pitfalls.

Thorough and state-of-the-art, Prenatal Diagnosis is an ideal volume for researchers and molecular biologists invested in ever-growing field of prenatal medicine.


Cell free fetal DNA Chromosom DNA FISH Fetal aneuploidies Fluorescence in situ hybridization (FISH) Fluoreszenz in situ-Hybridisierung High density nucleotide arrays (CHIPS) Microarray PCR PCR-based approaches Quantitative PCR genetics hybridization molecular biology

Editors and affiliations

  • Sinuhe Hahn
    • 1
  • Laird G. Jackson
    • 2
  1. 1.Laboratory for Prenatal Medicine and Gynecological Oncology, Department of BiomedicineUniversity Womens’s HospitalBasel
  2. 2.Department of Obstetrics and GynecologyDrexel University College of MedicinePhiladelphia

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-803-4
  • Online ISBN 978-1-59745-066-9
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site