The Cell Cycle in the Central Nervous System

  • Damir Janigro

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Cell Cycle During the Development of the Mammalian Central Nervous System

    1. Front Matter
      Pages 1-1
    2. Philippe Taupin
      Pages 13-22
    3. Gerald A. Grant, Damir Janigro
      Pages 31-41
    4. Giorgio Battaglia, Stefania Bassanini
      Pages 43-55
  3. Postnatal Development of Neurons and Glia

    1. Front Matter
      Pages 57-57
    2. P. Roy Walker, Dao Ly, Qing Y. Liu, Brandon Smith, Caroline Sodja, Marilena Ribecco et al.
      Pages 59-70
    3. Klaus van Leyen, Seong-Ryong Lee, Michael A. Moskowitz, Eng H. Lo
      Pages 71-79
    4. Annarosa Arcangeli, Andrea Becchetti
      Pages 81-94
    5. Xiuxin Liu, Anna J. Bolteus, Angélique Bordey
      Pages 95-104
    6. Yvan Arsenijevic
      Pages 119-139
  4. Control of the Cell Cycle and Apoptosis in Glia

    1. Front Matter
      Pages 141-141
    2. Brian T. Ragel, Bardia Amirlak, Ganesh Rao, William T. Couldwell
      Pages 143-161
    3. Kerri L. Hallene, Damir Janigro
      Pages 163-175
    4. Gabriele Dini, Erin V. Ilkanich, Damir Janigro
      Pages 177-191
  5. Adult Neurogenesis: A Mechanism for Brain Repair?

    1. Front Matter
      Pages 193-193
    2. Ljiljana Krizanac-Bengez
      Pages 207-219
    3. Danica B. Stanimirovic, Maria J. Moreno, Arsalan S. Haqqani
      Pages 233-244
    4. Lieve Moons, Peter Carmeliet, Mieke Dewerchin
      Pages 245-264
    5. Carmen Estrada, Antonio Villalobo
      Pages 265-277
  6. Cell Cycle Re-Entry: A Mechanism of Brain Disease?

    1. Front Matter
      Pages 279-279
    2. Randall D. York, Samantha A. Cicero, Karl Herrup
      Pages 281-297
    3. Katarzyna A. Gustaw, Gemma Casadesus, Robert P. Friedland, George Perry, Mark A. Smith
      Pages 299-308
    4. Jorge A. González-Martínez, William E. Bingaman, Imad M. Najm
      Pages 309-318
    5. Luca Cucullo
      Pages 319-329
    6. Amelia J. Eisch, Chitra D. Mandyam
      Pages 331-358
    7. Gemma Casadesus, Xiongwei Zhu, Hyoung-gon Lee, Michael W. Marlatt, Robert P. Friedland, Katarzyna A. Gustaw et al.
      Pages 359-370
  7. The Biology of Gliomas

    1. Front Matter
      Pages 371-371
    2. Shirley Teng, Micheline Piquette-Miller
      Pages 373-388
    3. Gurpreet S. Kapoor, Donald M. O’Rourke
      Pages 389-417
    4. Alexander M. Spence, David A. Mankoff, Joanne M. Wells, Mark Muzi, John R. Grierson, Janet F. Eary et al.
      Pages 419-432
    5. Sean E. Aeder, Isa M. Hussaini
      Pages 433-447
    6. Wei Zhang, Howard A. Fine
      Pages 449-462
  8. Future Directions

    1. Front Matter
      Pages 463-463
    2. Roberto Dal Toso, Sara Bonisegna
      Pages 465-475
    3. Yoshinaga Saeki
      Pages 477-493
    4. Barbara Aumayr, Damir Janigro
      Pages 525-540
  9. Back Matter
    Pages 541-563

About this book


It is now known that the adult mammalian brain undergoes repair and renewal from pools of stem cells and that cell cycle alteration may cause a variety of neurological disorders ranging from autism to brain tumors. In The Cell Cycle in the Central Nervous System, prominent researchers, physicians, engineers, and pharmacologists join forces to delineate how the brain is a complex organ composed of widely varying cell types, including blood vessels, and what its cellular-based disorders may be. Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system (CNS) to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
State-of-the-art and readily understandable, The Cell Cycle in the Central Nervous System illuminates our understanding of how brain development, disease, renewal, and repair may be mediated by vasculogenesis, neurogenesis, and the immune system, and offers an exciting variety of new research opportunities for all those investigating brain tumors, neurodevelopment, and neurological disorders.


Alzheimer Nervous System alzheimer's disease brain central nervous system cerebral ischemia death neurons positron emission tomography (PET) receptor tumor

Editors and affiliations

  • Damir Janigro
    • 1
  1. 1.The Cleveland Clinic FoundationCleveland

Bibliographic information