The G Protein-Coupled Receptors Handbook

  • Lakshmi A. Devi

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xv
  2. GPCRs: Structure and Function

    1. Front Matter
      Pages 1-1
    2. Dominique Massotte, Brigitte L. Kieffer
      Pages 3-31
    3. Ulla E. Petäjä-Repo, Michel Bouvier
      Pages 71-93
    4. James N. Hislop, Mark von Zastrow
      Pages 95-105
  3. GPCR Activity and Its Regulators

    1. Front Matter
      Pages 107-107
    2. Tracy Nguyen Hwangpo, Ravi Iyengar
      Pages 109-134
    3. Ryan W. Richman, María A. Diversé-Pierluissi
      Pages 135-148
    4. Lan Ma, Jingxia Gao, Xiaoqing Chen
      Pages 149-158
    5. Louis M. Luttrell
      Pages 159-198
    6. Hongyan Wang, Catherine B. Willmore, Jia Bei Wang
      Pages 199-213
  4. GPCR Dimerization/Oligomerization

    1. Front Matter
      Pages 215-215
    2. Karen M. Kroeger, Kevin D. G. Pfleger, Karin A. Eidne
      Pages 217-241
    3. Marta Filizola, Wen Guo, Jonathan A. Javitch, Harel Weinstein
      Pages 243-265
    4. Graeme Milligan, Juan J. Carrillo, Geraldine Pascal
      Pages 267-285
    5. Michael M. C. Kong, Christopher H. So, Brian F. O’Dowd, Susan R. George
      Pages 287-307
    6. Selena E. Bartlett, Jennifer L. Whistler
      Pages 309-322
    7. Noura S. Abul-Husn, Achla Gupta, Lakshmi A. Devi, Ivone Gomes
      Pages 323-346
  5. Recent Developments in Drug Discovery

    1. Front Matter
      Pages 347-347
    2. Andrew P. Smith, Nancy M. Lee
      Pages 349-362
    3. Xavier Deupi, Cedric Govaerts, Lei Shi, Jonathan A. Javitch, Leonardo Pardo, Juan Ballesteros
      Pages 363-388
    4. Rainer K. Reinscheid, Olivier Civelli
      Pages 389-401
  6. Back Matter
    Pages 403-412

About this book


G protein-coupled receptors (GPCRs) are involved in many processes in the human body relevant to health and disease, and consequently are the targets of approximately 70% of pharmacological therapeutics and a major source of new drug candidates. In The G Protein-Coupled Receptors Handbook, leading academic researchers comprehensively survey the many recent advances that have occurred in the GPCR field. The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors, and show how recent developments are leading to significant advances in drug discovery. They also discuss the most recent developments that could lead to new discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Authoritative and cutting-edge, The G Protein-Coupled Receptors Handbook offers pharmacologists, biochemists, and neuroscientists an exhaustive review of the progress made in understanding how GPCRs are activated and regulated, key factors in exploiting GPCRs for drug development.


Pflege cognition drug drug development drug discovery lead research

Editors and affiliations

  • Lakshmi A. Devi
    • 1
  1. 1.Department of Pharmacology and Biological ChemistryMount Sinai School of MedicineNew York

Bibliographic information