Table of contents

  1. Front Matter
    Pages i-xi
  2. Platelet Physiology

    1. Front Matter
      Pages 1-1
    2. Martin Quinn
      Pages 3-20
    3. Karlheinz Peter
      Pages 21-42
    4. Brian Savage, Zaverio M. Ruggeri
      Pages 43-69
    5. Elaine L. Bearer
      Pages 71-114
    6. Meinrad Gawaz
      Pages 115-147
    7. Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, Andrew S. Weyrich
      Pages 149-174
    8. Katrin Marcus, Helmut E. Meyer
      Pages 175-198
  3. Assessing Platelet Function

    1. Front Matter
      Pages 199-199
    2. Dermot Cox
      Pages 201-222
    3. José A. López, Ian del Conde, Jing-Fei Dong
      Pages 223-246
    4. Lisa K. Jennings, Melanie M. White
      Pages 247-266
    5. Bianca Rocca, Carlo Patrono
      Pages 267-281
    6. Michael Kalafatis, Emil Negrescu, Tatiana Byzova, Edward F. Plow
      Pages 283-300
    7. Alan D. Michelson, Mark I. Furman
      Pages 301-314
    8. Andrew Maree, James McRedmond
      Pages 315-331
  4. Clinical Applications

    1. Front Matter
      Pages 333-333
    2. Jacqueline Saw, David J. Moliterno
      Pages 335-367

About this book

Introduction

Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.
Comprehensive and state of the art, Platelet Function: Assessment, Diagnosis, and Treatment offers vascular researchers and clinicians a sound foundation for understanding platelet biology, assessing thrombotic risk in patients, and determining the rational dosing of antiplatelet agents.

Keywords

antiplatelet therapy pharmacodynamics physiology platelet thromboxane

Editors and affiliations

  • Martin Quinn
    • 1
  • Desmond Fitzgerald
    • 2
  1. 1.Department of CardiologySt. Vincent’s University HospitalDublinIreland
  2. 2.University College DublinDublinIreland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-917-2
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-244-5
  • Online ISBN 978-1-59259-917-2
  • About this book