Bioimaging in Neurodegeneration

  • Patricia A. Broderick
  • David N. Rahni
  • Edwin H. Kolodny

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Parkinson’s Disease

    1. Front Matter
      Pages 1-1
    2. André R. Troiano, A. Jon Stoessl
      Pages 25-35
    3. Hubert H. Fernandez, Paula D. Ravin, Dylan P. Wint
      Pages 37-44
    4. Yilong Ma, Vijay Dhawan, Curt Freed, Stanley Fahn, David Eidelberg
      Pages 45-57
  3. Alzheimer’s Disease

    1. Front Matter
      Pages 59-59
    2. Ladislav Volicer, Monika Z. Wrona, Wayne Matson, Glenn Dryhurst
      Pages 85-93
    3. Kejal Kantarci, Clifford R. Jack Jr.
      Pages 95-105
  4. Epilepsy

    1. Front Matter
      Pages 121-121
    2. Jun Natsume, Andrea Bernasconi, Mirko Diksic
      Pages 123-129
    3. Bharathi Dasan Jagadeesan, Csaba Juhász, Diane C. Chugani, Harry T. Chugani
      Pages 131-140
    4. Steven V. Pacia, Patricia A. Broderick
      Pages 141-147
    5. Sonya Bahar, Minah Suh, Ashesh Mehta, Theodore H. Schwartz
      Pages 149-175
    6. Patricia A. Broderick, Steven V. Pacia
      Pages 199-206
  5. Leukodystrophy (White Matter) Diseases

    1. Front Matter
      Pages 207-207
    2. Edwin H. Kolodny
      Pages 209-214
    3. Laura Farina, Alberto Bizzi, Mario Savoiardo
      Pages 215-223
    4. Annette O. Nusbaum
      Pages 225-238
    5. Edwin Y. Wang, Meng Law
      Pages 239-260
    6. Graham J. Kemp
      Pages 297-308
  6. Back Matter
    Pages 309-313

About this book


New imaging sensors, molecular probes, and neuromarkers for faster temporal resolution, smaller spatial resolution, and higher anatomic accuracy have made brain neuroimaging highly valuable in studying neuropathologies. Provocative insights into how the human brain actually works in real time and in vivo are now possible. In Bioimaging in Neurodegeneration, prominent physicians, researchers, and inventors of cutting-edge technologies review the new imaging tools available for diagnosing, treating, and discovering the underlying causes of Parkinson's and Alzheimer's disease, epilepsy, and leukodystrophy. The new technologies demonstrated include novel sequences for magnetic resonance imaging (MRI), such as magnetization-prepared rapid acquisition gradient echo (MPRAGE); proton magnetic resonance spectroscopy (1H MRS); new tracers for positron emission tomography (PET) and single-photon emission tomography (SPECT), such as tropane analogs and altropane; neuromolecular imaging (NMI) of neurotransmitters directly in brain synapses of epilepsy patients with unique carbon-based electrochemical sensors; and intrinsic optical signal imaging (IOS), useful in diagnosing "spreading epileptiform depression." NMI and IOS also promise applications in intraoperative guided neurosurgery. Pediatric mitochondrial cytopathies are discussed, as well as nanotechnology, microtechnology, nanoimaging, and microimaging are presented. Devices for diagnosing tumors are also described. To enhance understanding of the potential of these developing technologies, a companion compact disk contains color versions of selected black-and-white illustrations used in the book.
Authoritative and state-of-the art, Bioimaging in Neurodegeneration offers both the physician and researcher a critical survey of the best new technologies for studying neurodegeneration, as well as describing their optimal use in the diagnosis and treatment of specific neurodegenerative diseases.


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Editors and affiliations

  • Patricia A. Broderick
    • 1
    • 2
    • 3
  • David N. Rahni
    • 4
  • Edwin H. Kolodny
    • 2
  1. 1.Department of Physiology and PharmacologyCity University of New York Medical SchoolNew York
  2. 2.Department of NeurologyNew York University School of MedicineNew York
  3. 3.NYU Comprehensive Epilepsy CenterNew York
  4. 4.Department of Chemistry and Physical SciencesPace UniversityPleasantville

Bibliographic information