Signal Transduction and the Gasotransmitters

NO, CO, and H2S in Biology and Medicine

  • Rui Wang

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Gasotransmitters: Past, Present, and Future

    1. Front Matter
      Pages 1-1
    2. Ray J. Carson, Gunter Seyffarth, Rubina Mian, Helen Maddock
      Pages 33-55
  3. The Emergence of the First Gasotransmitter: Nitric Oxide

    1. Front Matter
      Pages 57-57
    2. Chris R. Triggle, Hong Ding, Ella S. M. Ng, Anthie Ellis
      Pages 59-94
    3. Allan Doctor, Benjamin M. Gaston
      Pages 95-107
    4. Shoji Sanada, Jiyoong Kim, Masafumi Kitakaze
      Pages 109-122
    5. Claudio Grassi, Marcello D’Ascenzo, Gian Battista Azzena
      Pages 137-155
    6. Zhao Zhang, Kathryn A. Glatter, Nipavan Chiamvimonvat
      Pages 157-168
    7. Marie-Christine Broillet
      Pages 169-183
  4. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter

  5. Gas of the Rotten Egg: Hydrogen Sulfide as the Third Gasotransmitter

  6. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism

    1. Front Matter
      Pages 357-357
  7. Back Matter
    Pages 371-377

About this book


Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.
Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.


ATP Calcium Nucleotide biology cell environment metabolism protein synthesis tissue

Editors and affiliations

  • Rui Wang
    • 1
  1. 1.Department of PhysiologyUniversity of SaskatchewanSaskatoonCanada

Bibliographic information