IGF and Nutrition in Health and Disease

  • M. Sue Houston
  • Jeffrey M. P. Holly
  • Eva L. Feldman

Part of the Nutrition and Health book series (NH)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Martin L. Adamo, Lai Wang, Lisa Heron, Dalit Ben-Yosef, Hong Zhao, Derek Le Roith
      Pages 3-22
  3. IGF and Nutritional Status

    1. Front Matter
      Pages 23-23
    2. Jean-Paul Thissen, Véronique Beauloye, Jean-Marie Ketelslegers, Louis E. Underwood
      Pages 25-52
  4. Growth and Development

    1. Front Matter
      Pages 105-105
    2. Cynthia L. Blanco, Robert J. Ferry Jr.
      Pages 133-143
    3. Frank A. Simmen, Inseok Kwak, Jason L. Blum, Rosalia C. M. Simmen
      Pages 145-155
    4. Moira S. Lewitt, Kerstin Hall
      Pages 157-174
  5. IGF and Organ Systems

    1. Front Matter
      Pages 175-175
    2. Jean-Philippe Bonjour, Patrick Ammann, Thierry Chevalley, René Rizzoli
      Pages 177-192
    3. Gary Meyer, Aparna Bole, Eva L. Feldman
      Pages 211-225
    4. Ralph Rabkin, Steven S. Guest, Franz Schaefer
      Pages 227-247
  6. IGF in Disease States

  7. Back Matter
    Pages 343-358

About this book


From birth to death, the insulin-like growth factors (IGF) -a system of proteins, binding proteins, and cell receptors that are widely expressed in all tissues-plays critical roles in metabolism, normal growth and development, and numerous acute and chronic diseases. The IGF system is fundamentally related to growth hormone and insulin, but also nutritional state. In IGF and Nutrition in Health and Disease, leading researchers and physicians from diverse disciplines comprehensively review for the first time how specific nutrients or adverse nutritional states impact gene expression, circulating concentrations, and bioactivity of the IGF proteins. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, and examine the interactions between IGF and nutritional status from the molecular to the population levels. Their discussion of the essential interrelationships between IGF and nutrition, including specific nutrients, in physical development across the life span illuminates the balance between normal growth and development and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.
Comprehensive and authoritative, IGF and Nutrition in Health and Disease is a benchmark review of nutrition and the IGF system in human health and disease, providing a clear understanding of the critical importance of the IGF system and nutritional state to human growth, metabolism, disease development, and therapy.


Diabetes Diabetes mellitus Insulin Malnutrition Nutrition bone health cancer growth factor insulin-like metabolism

Editors and affiliations

  • M. Sue Houston
    • 1
  • Jeffrey M. P. Holly
    • 2
  • Eva L. Feldman
    • 3
  1. 1.Food and Nutrition Program, School of Family and ConsumerBowling Green State UniversityBowling GreenUSA
  2. 2.Division of Surgery, Department of Hospital MedicineBristol Royal InfirmaryBristolUK
  3. 3.JDRF Center for the Study of Complications in Diabetes, Department of NeurologyUniversity of MichiganAnn ArborUSA

Bibliographic information