Cancer Gene Therapy

  • David T. Curiel
  • Joanne T. Douglas

Part of the Contemporary Cancer Research book series (CCR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Malcolm K. Brenner
    Pages 1-8
  3. Akseli Hemminki, Kari Hemminki
    Pages 9-18
  4. Jack A. Roth, Susan F. Grammer
    Pages 19-33
  5. Ruiwen Zhang, Hui Wang
    Pages 35-49
  6. Lisa Scherer, John J. Rossi
    Pages 51-63
  7. Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, Richard Vile
    Pages 65-80
  8. Caroline J. Springer, Ion Niculescu-Duvaz
    Pages 81-107
  9. Daniel H. Palmer, David J. Kerr
    Pages 109-128
  10. Denise R. Shaw, Albert F. LoBuglio
    Pages 129-141
  11. Tanja D. de Gruijl, Herbert M. Pinedo, Rik J. Scheper
    Pages 143-172
  12. Weiping Zou, Shuang Wei, Tyler J. Curiel
    Pages 173-184
  13. Theresa V. Strong
    Pages 185-197
  14. John A. Howe, Robert Ralston, Murali Ramachandra
    Pages 211-233
  15. Megan K. Patrick, Kara L. Norman, Patrick W. K. Lee
    Pages 249-260
  16. Steve Gyorffy, Jack Gauldie, A. Keith Stewart, Xiao-Yan Wen
    Pages 261-271
  17. David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, James S. Norris
    Pages 273-286
  18. Duen-Hwa Yan, Kung-Ming Rau, Mien-Chie Hung
    Pages 287-298

About this book

Introduction

Today a new generation of powerful cancer therapeutics targeted against the molecular pathways that produce malignant phenotypes is rapidly emerging. In Cancer Gene Therapy, leading basic and clinical cancer oncologists provide a complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. In their discussions, the authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Authoritative and wide ranging, Cancer Gene Therapy offers a comprehensive survey of the molecular basis of cancer gene therapy and demonstrates its enormous potential to take a place in the clinic alongside the current generation of anticancer therapeutics.

Keywords

cancer treatment clinical trial gene therapy gene transfer imaging immune system immunotherapy metastasis prostate cancer tumor

Editors and affiliations

  • David T. Curiel
    • 1
    • 2
    • 3
    • 4
  • Joanne T. Douglas
    • 1
    • 2
    • 3
    • 4
  1. 1.Division of Human Gene Therapy, Department of MedicineUniversity of Alabama at BirminghamBirmingham
  2. 2.Division of Human Gene Therapy, Department of PathologyUniversity of Alabama at BirminghamBirmingham
  3. 3.Division of Human Gene Therapy, Department of SurgeryUniversity of Alabama at BirminghamBirmingham
  4. 4.Division of Human Gene Therapy, Department of Gene Therapy CenterUniversity of Alabama at BirminghamBirmingham

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-785-7
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-58829-213-1
  • Online ISBN 978-1-59259-785-7
  • About this book