Nucleic Acid Therapeutics in Cancer

  • Alan M. Gewirtz

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction and Perspective

    1. Front Matter
      Pages 1-1
    2. Fritz Eckstein
      Pages 3-13
    3. Alan M. Gewirtz
      Pages 15-24
  3. Basic Methodology

    1. Front Matter
      Pages 25-25
    2. Faye A. Rogers, Peter M. Glazer
      Pages 27-43
    3. John J. Rossi
      Pages 45-64
    4. David A. Dunbar, Susan J. Baserga
      Pages 81-88
    5. Zuo Zhang, Gordon G. Carmichael
      Pages 89-104
  4. Delivery

    1. Front Matter
      Pages 105-105
    2. R. L. Juliano
      Pages 107-113
    3. Eric Vivès, Jean Philippe Richard, Bernard Lebleu
      Pages 115-127
    4. Guy Zuber, Jean-Serge Remy, Patrick Erbacher, Pascale Belguise, Jean-Paul Behr
      Pages 129-140
  5. Targeting

    1. Front Matter
      Pages 141-141
    2. Rosel Kretschmer-Kazemi Far, Jens M. Warnecke, Georg Sczakiel
      Pages 143-154
    3. Lida K. Gifford, Ponzy Lu, Alan M. Gewirtz
      Pages 155-163
  6. Clinical Targets

    1. Front Matter
      Pages 165-165
    2. Joanna B. Opalinska, Susan E. Shetzline
      Pages 167-176
    3. C. A. Stein, Nathalie Dias, Luba Benimetskaya, Jan S. Jepsen, Johnathan C. H. Lai, Anthony J. Raffo
      Pages 177-197
  7. Back Matter
    Pages 213-221

About this book


The development of effectively targeted and efficiently delivered nucleic acids promises important advances in the diagnosis and treatment of human malignancies. In Nucleic Acid Therapeutics in Cancer, leading researchers, academic physicians, and clinicians clearly and succinctly review the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting methods and specific clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Concise yet highly readable, Nucleic Acid Therapeutics in Cancer offers those who require a cutting-edge critical synthesis not only a state-of-the-art account of this promising field, but also an illuminating introduction to their emerging therapeutic uses.


DNA cancer tumor tumor growth

Editors and affiliations

  • Alan M. Gewirtz
    • 1
  1. 1.Department of Internal MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

Bibliographic information