The Skeleton

Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis

  • Edward J. Massaro
  • John M. Rogers

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Chondrogenesis, Chondrocytes, and Cartilage

    1. Front Matter
      Pages 1-1
    2. Lillian Shum, Yuji Hatakeyama, Julius Leyton, Kazuaki Nonaka
      Pages 17-42
    3. Andreia M. Ionescu, M. Hicham Drissi, Regis J. O’Keefe
      Pages 43-53
    4. Johanna Myllyharju
      Pages 77-87
  3. Control of Skeletal Development

    1. Front Matter
      Pages 99-99
    2. Marie Kmita, Denis Duboule, József Zákány
      Pages 101-112
    3. Renee Hackenmiller, Catherine Degnin, Jan Christian
      Pages 113-130
    4. Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi et al.
      Pages 131-145
    5. Andrea D. Weston, T. Michael Underhill
      Pages 147-157
    6. Maurizio Pacifici, Chiara Gentili, Eleanor Golden, Eiki Koyama
      Pages 159-170
  4. Osteoblastic Cell Differentiation

  5. Bone Induction, Growth, and Remodeling

    1. Front Matter
      Pages 215-215
    2. Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, Louise Renton
      Pages 217-227
    3. Dana L. Di Nino, Thomas F. Linsenmayer
      Pages 229-247
    4. Jacqueline C. van der Linden, Harrie Weinans, Jan A. N. Verhaar
      Pages 249-261
  6. Bone Mineralization

    1. Front Matter
      Pages 277-277
    2. Siegfried Arnold, Hans J. Höhling, Ulrich Plate
      Pages 279-292
    3. Christopher S. Kovacs
      Pages 293-306
    4. Johannes P. T. M. van Leeuwen, Marjolein van Driel, Hulbert A. P. Pols
      Pages 307-332
  7. Skeletal Dysmorphology

    1. Front Matter
      Pages 333-333
    2. Giedre Grigelioniene
      Pages 349-359
    3. Michael G. Narotsky, Nathalie Wéry, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard et al.
      Pages 361-372
    4. John M. Rogers, R. Woodrow Setzer, Neil Chernoff
      Pages 373-383
    5. Rochelle W. Tyl, Melissa C. Marr, Christina B. Myers
      Pages 385-413
  8. Back Matter
    Pages 415-428

About this book


The skeleton is a complex multifunctional system. In addition to its mechanical/structural support function, it is, as the major reservoir of calcium, intimately involved in intracellular signaling pathways of critical importance both in the complex process of development and the maintenance of physiologic homeostasis. It is also, as the major source of blood cells, a critical part of the circulatory, respiratory, and immune systems. In The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis, established biomedical researchers, developmental biologists, and clinical practitioners offer a cutting-edge survey of diverse critical issues in bone biology. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors focus on the biochemical, genetic, and molecular interactions that support the development and homeostasis of the skeleton. Their state-of-the-art understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity (space flight), and hastening the healing of fractures, osteotomies, and arthrodeses. Equally important are their insights into metaphyseal fractures in the aged, into the mechanism(s) of osteopenia and osteoporosis, and into how and why, during menopause, healthy women lose only bone adjacent to the marrow.
Authoritative and up-to-date, The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis offers biomedical and clinical researchers rapid access to the latest understanding of the biochemistry, physiology, pharmacology, genetics, molecular biology, developmental biology, and aging of the skeleton.


biology bone cartilage cell fracture implant morphology osteotomy physiology skeleton tissue

Editors and affiliations

  • Edward J. Massaro
    • 1
  • John M. Rogers
    • 1
  1. 1.Developmental Biology Branch, Reproductive Toxicology Division, The National Health and Environmental Effects Research Laboratory, Office of Research DevelopmentUnited States Environmental Protection AgencyResearch Triangle ParkUSA

Bibliographic information